Different heterocyclic analogues were evaluated for their diverse biological activities. Out of them, the 1,2,4-triazole nucleus is an ubiquitous structural feature of many synthetic compounds with diversified therapeutic efficacy. A large volume of published literature over the last few decades precludes a comprehensive review. The triazole moiety seems to be very small but its broad biological profile has attracted the attention of many researchers to explore this skeleton to its multiple potential against several activities. This article presents a comprehensive review on the pharmacological activities of some novel derivatives of the 1,2,4-triazole moiety.

Review: 90 refs.

Heterocyclic chemistry comprises at least half of all organic chemistry research worldwide. Quinazolinone and its derivatives constitute an important class of heterocyclic compounds. The chemistry of quinazoline compounds has more than centuries old history; however the intense search for biologically active substances in this series began only in the last few decades. In this present communication an attempt is made to cover the medicinally active compounds, along with the recent discoveries, which were reported to posses various biological activities.

Microwave Synthesis as a Part of Green Chemistry for the Synthesis of Novel 1,2,4-Triazole Derivatives -[79 refs.]. -(CHAWLA, A.; KAUR, P.; Int. Res. J. Pharm. 4 (2013) 1, 49-72, http://dx.doi.org/10.7897/2230-8407.04309 ; CT Inst. Pharm. Sci., Jalandhar 144 008, Punjab, India; Eng.) -Lindner 36-203

A facile synthesis of series of 2-amino-3,4,5-triphenyl-1H-imidazole was carried out. In the present research work, with the help of microwave irradiations the above said compounds were synthesised and also wherever necessary their synthesis was assisted by the use of catalyst. The method possessed remarkable advantages, such as short reaction time and moderate to excellent yield. Microwaves provide environment friendly reactions by the use of lesser expensive polar solvents. Finally, all synthesised compounds were evaluated for antioxidant activity by reducing power method and DPPH free radical scavenging assay method.