Objective: To determine the cost of achieving a live birth after first transfer using highly purified human menotropin (HP-hMG) or recombinant follicle-stimulating hormone (FSH) for controlled ovarian stimulation in predicted high-responder patients in the Menopur in Gonadotropin-releasing hormone Antagonist Single Embryo Transfer-High Responder (MEGASET-HR) trial. Design: Cost minimization analysis of trial results. Setting: Thirty-one fertility centers. Patient(s): Six hundred and nineteen women with serum antim€ ullerian hormone R5 ng/mL. Intervention(s): Controlled ovarian stimulation with HP-hMG or recombinant FSH in a gonadotropin-releasing hormone (GnRH) antagonist assisted reproduction cycle where fresh transfer of a single blastocyst was performed unless ovarian response was excessive whereupon all embryos were cryopreserved and patients could undergo subsequent frozen blastocyst transfer within 6 months of randomization. Main Outcome Measure(s): Mean cost of achieving live birth after first transfer (fresh or frozen). Result(s): First-transfer efficacy, defined as live birth after first fresh or frozen transfer, was 54.5% for HP-hMG and 48.0% for recombinant FSH (difference 6.5%). Average cost to achieve a live birth after first transfer (fresh or frozen) was lower with HP-hMG compared with recombinant FSH. For fresh transfers, the cost was lower with HP-hMG compared with recombinant FSH. The average cost to achieve a live birth after first frozen transfer was also lower in patients treated with HP-hMG compared with recombinant FSH.

EBL). Spearman's correlation was used to evaluate the correlation between leiomyomata volume and operative outcomes. Receiver-operator-characteristic (ROC) curves were constructed for outcomes showing statistical significance.RESULTS: A total of 117 patients were included; there was no difference in the demographics or leiomyomata characteristics of patients undergoing MRI or US in the AM (n¼69), LM (n¼13) or RALM (n¼35) groups. The mean age and leiomyomata volume of patients undergoing LM was 36.7AE7.1 years and 152.1AE90.9 mL, respectively. The was a strong positive correlation between MRI leiomyomata volume and operating time (rho¼0.90; P<0.001) and leiomyomata weight (rho¼0.89; P¼0.02). Patients in the RALM group had a mean age and leiomyomata volume of 36.9AE4.1 years and 242.4AE136.1 mL, respectively. A significant positive correlation between MRI leiomyomata volume and operating time (rho¼0.83; P¼0.03) and leiomyomata weight (rho¼0.79; P¼0.01) was noted in the RM group as well. These correlations were non-significant in the LM and RALM groups when using US leiomyomata volume. MRI leiomyomata volume was also predictive of LM and RALM conversion to laparotomy (area-under-the-curve¼0.92).

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legal and financial obstacles. Based on this survey, providers should be aware of educational levels, financial costs, and a common desire for two genetically-related intended fathers.