The article discusses the regional aspects of the formation of cooperative ties between science and business. The level of cooperation of enterprises with scientific and educational organizations is presented as an important criterion for the organization of high-tech production. The relevance of the article lies in the need to solve the problems of managing joint innovative projects in Russian regions. The purpose of the article is to identify trends and factors that influence the development of cooperative ties in regional production systems of various levels of manufacturability. As the main research methods, the article used the description method to determine the level and trends of innovative development of Russian regions; the method of correlation analysis, which established the factors that have the greatest influence on the degree of cooperation of scientific organizations and industrial enterprises in the development of technological innovations. The article presents an analysis of the dynamics of innovative development of the industrial sector of the Russian regions; the interrelation of factors affecting the degree of cooperation between science and business in the development of technological innovations is determined. The materials of the article can be used in the development of organizational and managerial decisions aimed at enhancing the innovative development of territories, the organization of high-tech industries, taking into account the cooperation of scientific organizations and business.

The paper considers the selection of priority innovative programs as a plan for technical development and production organization. Various financing alternatives are reviewed in the form of mathematical models for the coordination of interests between players of relationships. The pseudo-Boolean optimization methods are used as the main method for implementing models. An optimal investment plan is the result of problems solving.