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It is evident that the flow kinematic parameters play a considerable role in the generation of secondary flows within complex geometries and that they affect the hydrodynamic behavior of fluid mixing. The intensity of these parameters has remarkable effects on the mixing performance improvement in passive micromixers. Helicity density, rotation rate, strain rate, and vortex intensity are presented as indispensable tools for the graphical representation of three-dimensional flow fields containing vortex zones. The use of these quantities shows the regions of the flow field with low and strong vorticity regions. In this work, the fluid mixing performances using a short two-layer crossing channel micromixer were analyzed. Navier−Stokes equation, continuity equation, and species transport equation are solved numerically using a CFD code with Reynolds number values between 0.2 and 70. Moreover, the physical model used to assess the mixing quality is the species transport model. The results show that the micromixer with l/W = 1 has a high potential of secondary flows, which promote the enhancement of the hydrodynamic mixing efficiency, where the mixing index exceeded 90% from Re = 20 and reached 99.78% at Re = 70. Moreover, the maximum value of MEC obtained for Re = 70 is equal to 111.48 μW, which represents a low value.