The tribological performance of a glass fiber reinforced polyamide66 (GFRPA66) composite with varying fiber weight percentage (wt.%) [30 wt.% and 35 wt.%] is investigated in this study using a pin-on-disc tribometer. GFRPA66 composite specimens in the form of pins with varying percentages of fiber viz., 30 wt.% and 35 wt.% are fabricated by an injection molding process. Tribological performances, such as coefficient of friction (COF) and the specific wear rate (SWR), are investigated. The factors affecting the wear of GFRPA66 composites [with 30 wt.% and 35 wt.% reinforcements] are identified based on the process parameters such as load, sliding velocity, and sliding distance. Design Expert 13.0 software is used for the experimental data analysis, based on the design of experiments planned in accordance with the central composite design (CCD) of the response surface methodology (RSM) technique. The significance of the obtained results are analyzed using analysis of variance (ANOVA) techniques. To attain minimum SWR and COF, the wear performance is optimized in dry sliding conditions. The analysis of experimental data revealed that SWR and COF increased with increasing load, sliding velocity, and sliding distance for GFRPA66 [30 wt.%], but decreased with increasing polyamide weight percentage. The SWR for a maximum load of 80 N, and for a sliding velocity of 0.22 m/s, and a sliding distance of 3500 m for GFRPA66 composite specimens with 30 wt.% reinforcements are found to be 0.0121 m3/Nm, while the SWR for the same set of parameters for GFRPA66 composite specimens with 35 wt.% reinforcements are found to be 0.0102 m3/Nm. The COF for the GFRPA66 composite specimens with 30 wt.% reinforcements for the above set of parameters is found to be 0.37, while the GFRPA66 composite specimens with 35 wt.% reinforcements showed significant improvement in wear performance with a reduction in COF to 0.25. Finally, using a scanning electron microscope (SEM), the worn surfaces of the GFRPA66 are examined and interpreted.