Aim: To assess the outcome of haematological and haemostatic indices in hospitalized Yellow Fever Positive patients treated using levels of full blood count, platelet count and other red cell indices at the Centre for Communicable Disease and Research (CCDCR) Federal Medical Centre, Asaba, Delta State, Nigeria. Study Design:  Retrospective observational study. Place and Duration of Study: Centre for Communicable Disease Control and Research (CCDCR), Federal Medical Centre Asaba, Nigeria, between August and December 2020. Methodology: Descriptive data was collected from the records of fifty-six (56) patients aged 16 – 65 years who were hospitalized and treated at the CCDCR FMC Asaba, within the months of August to December, 2020 and 56 non-Yellow Fever subjects as control subjects. The patients’ samples were previously collected and analyzed for haematological parameters (neutrophil, eosinophil, basophil, lymphocytes, monocytes, platelet count, mean cell volume (MCV), mean cell haemoglobin (MCH) and mean cell haemoglobin concentration (MCHC), using an automated haematology analyzer. Data collected was analyzed using SPSS version 25 and P values less than .05 were considered statistically significant.  Results: There were higher levels of total white blood cell count, eosinophil and MCH in hospitalized yellow fever patients when compared with the control group (P < 0.05). On the other hand, there was a lower level in platelet count of hospitalized yellow fever patients when compared with non-yellow fever control subjects (P < 0.05).  There was no significant difference in other haematological indices assayed which appeared normal (P > 0.05). Conclusion: In conclusion, it can be inferred that yellow fever can be associated with several haematological derangements which this study has succeeded to lay bare. Understanding these characteristics aids in planning therapy, management of patients as well as monitoring outcome.