BACKGROUND:Behçet’s syndrome is associated with inflammation of various areas of the body. Sy. Behcet is a rare, chronic, recurrent disease characterised by changes in the: Arteries that supply blood to the body’s tissues, veins that take the blood back to the lungs, the back of the eye’s retina, brain, joints, skin and bowels. There is a close correlation between the geographical distribution of HLA-B51 and its prevalence. In the etiopathogenesis, there are indications of genetic susceptibility associated with environmental influence. Although aetiology is not yet known, it is thought of viral or autoimmune genes but is not yet confirmed by relevant analysis.CASE REPORT:This was a case of a 29 years old young female presenting with recurrent oral and genital ulcers. Eye lesions usually start in one eye and then pass to the other eye. They are like iridocyclitis extending very quickly to another eye. Three months later, a few shifts were introduced in the form of small initial ulcers, which for 4-5 days have been enlarged and then epithelized by leaving the catapult in the genital mucus. In the skin of the lower extremities, papules appear to be as large as corn grain.CONCLUSION:Diagnosis of Behçet’s syndrome is determined based on eye changes, oral mucous and genital mucosa. Treatment of Behçet’s syndrome depends on the severity and the location of its manifestations.

Background: Malum perforans pedis is a chronic disease characterized by a punched out ulceration that may enlarge. The ulcer is localisated in a foot. It is a complication of the primary disease of the different origin that is always presented with a vaculopathies or neuropathies, and is common in diabetic patients. Malum perforans pedis appears in a sole of the foot and mostly occurs with no pain. The disease is mostly caused by the pressing of the underlain bone and a chronic trauma on a poor blood flow of the tissue. The treatment consists: on a treatment of the primary disease-vaculopathy and neuropathy; the local treatment includes treatment of the infection and the wound treatment through surgery and skin grafting. Case presentation: This paper presents a case of a 49 year old woman with the ulceration on a sole of the left foot that did appeared before four months. The patient claims that the changes began after wearing shoes that hurt her foot. The patient also claims that during the past year she had some signs of diabetes and the measure of the blood sugar shows high levels. The patient also gives interesting data that during the last few years she have had used cosmetics which contained mercury. Conclusions: Malum perforans pedis is a disease where the patient loses the feeling of pain and the chronic trauma causes the injury and following that during the time the defect in a skin enlarges and makes a trophic ulcer in a various size and form. It also depends on a microangiopathies due to diabetes and arteriosclerosis.

Atrophoderma of Pasini and Pierini is a skin atrophy presenting as single or multiple sharply demarcated, hyperpigmented, non-indurated patches, with a slight depression of the skin, that can converge and form a confluent area with atrophy as a consequence. The condition was first described by Pasini in 1923 and subsequently by Pierini in 1936. They distinguished this form of atrophy from other diseases and conditions in which the atrophy is morphologically and clinically different. The disease was initially associated with Borrelia burgdorferi infection; however, at present, various theories have emerged for the appearance of the disease, linked to genetic, neurogenetic, and immunological factors. Here we present a patient that was admitted to the hospital due to disseminated lesions on the skin of the lower limbs, with slightly pigmented and atrophic skin along with irregular borders varying in size, from several mm to a few cm, clearly demarcated from the healthy skin, with no history of a tick bite or a family history of similar skin disorders.

Lyme borreliosis is an infective disease that is usually transmitted to humans via biting by bacteria-infected Ixodes tick. The disease is multisystemic and the affected organs are the skin (Erythema migrans), nervous system, eyes, heart and joints. Borrelia burgdorferi is the bacterium that causes borreliosis and the hosts are rodents of the genus Apodemus. In the Balkan region, Ixodes ricinus is the most representative vector. A bite from an infected insect is the most common mode of transmitting Borrelia; however, transplacental transmission has also been documented. Pathogenesis of the disease consists of both direct and indirect mechanisms of immunological reactions which result in the production of IgM antibodies to Borrelia in the first 3-6 weeks, and production of IgG class after 6 weeks. Many skin diseases and skin symptoms mimicking Lyme borreliosis, such as dermatomycosis, erysipelas, and undefined hyperpigmentation must be elaborated and considered for borreliosis, as skin symptoms of borreliosis can imitate many of them.

examination. And on rectal smear microscopy, 31.5% had pus cells (OR 2.16, p < 0.001) and 44.1% had gramme negative diplococci with/without pus cells (OR 1.60, p = 0.016).Algorithms using ano-rectal symptom as entry point had poor sensitivity (0.8%). The algorithm using receptive anal sex and/or complaint of ano-rectal discharge as the entry point, and subsequently using proctoscopic and/or rectal smear findings had a sensitivity, specificity and positive predictive value of 41.7, 66.3 and 17.5, respectively. By adding risk assessment, the algorithm performance values changed to 81.9, 20.1 and 14.9, respectively. Conclusion Effectiveness of flow-charts for syndromic management of ARD is constrained by the asymptomatic nature of rectal NG/CT. Algorithms including receptive anal sex at entry point and applying risk assessment, clinical and rectal smear examination may be useful for management of rectal NG/CT in resource limited settings, until cheaper, reliable and feasible laboratory tests are made available. DysPareunia among Women ageD 40 to 60 years infecteD With hiV