IntroductionAcne and hirsutism are common manifestations of hyperandrogenism.AimTo investigate whether or not acne is present in women with hirsutism, associated with different clinical, endocrine and ultrasonographic features.Material and methodsThe prospective study included 135 women with hirsutism, aged 14–46 years. We measured the levels of hormones with radioimmunoassay/immunoradiometric assay methods.ResultsAcne were present in 63 (47.6%) women with hirsutism. Sixty women had mild forms of acne, including: whiteheads, blackheads, papules and pustules. Only 3 women had moderate to severe acne, including nodules. In a group of women with hirsutism and acne, 6 (9.5%) were obese. In our study we found a high prevalence of androgen excess among hirsute women with acne: total testosterone was increased in 79%, free testosterone in 20.6%, androstenedione in 69.8%, dehydroepiandrosterone sulfate (DHEAS) in 30.1%, 17-OH-progesterone 68.2% and sex hormone-binding globulin (SHBG) was decreased in 33.3% of women. Women with hirsutism and acne have received oral contraceptives for a year, without or in a combination with other medication. Thirty-four (53.9%) women have shown improvement in hirsutism and acne.ConclusionsIn this study we found a high prevalence of acne in hirsute women. The prevalence of acne was higher in polycystic ovarian syndrome. Since these women have associated endocrine changes it is important to correct them with hormonal therapy.

Background: Erythema multiforme (EM) is a distinctive hypersensitivity syndrome characterized by skin and mucous membrane lesions and in its more severe forms, visceral involvement. The condition varies from a mild, selflimited rash to a severe, life-threatening form. The most common predisposing infection is Herpes simplex, but bacterial infections, fungal diseases and drugs are also implicated. The literature cites that half of children with the rash have recent herpes labialis. Methods: This is a case report of a 12 years old male patient. The patient had herpes simplex labialis by admission in our clinic. The patient had recurrent infection from 6 years of age with clinical appearance two times per year. In both situations, it was followed by erythema multiforme with one week latter onset. This is the second time that he developed acutely typical target skin lesions, on the face and extensor surfaces of hands. The lesions were distributed symmetrically and spreading centrally. Conclusions: Although the etiology of EM is still often unknown, infections with herpes simplex virus have been implicated as common predisposing a possible precipitating factor. This case illustrates the association of the occurrence of EM with a herpes simplex virus (HSV) infection and antiviral drugs are necessary to given for future prophylaxis of recurrence of both clinical features.

Erythema exsudativum multiforme is an immunologically mediated skin reaction or a reaction to viruses or bacteria (10), classified in the group of type-IV delayed cell-mediated hypersensitivity. The minor form is localized on the skin and the mucosa are not involved (1, 9). The typical skin sign is herpes iris, or target lesions with a red to reddish-blue color. The localization of the changes occur in photo-exposed areas. The main causes are various drugs, food containing some additives, bacteria, especially streptococcus, and some viruses, such

a im: Renal agenesis is a fairly common congenital anomaly with an unknown definite etiology. Unilateral renal agenesis is much more common than bilateral renal agenesis, but it usually does not carry any major health consequence, as long as the other kidney is healthy. In some cases, renal agenesis may by associated with other congenital anomalies. We report a neonatal female patient born with unilateral renal agenesis associated with malrotation of ipsilateral kidney, anal atresia and pulmonary artery failure. Material and methods: One month old female child was referred to Nuclear Medicine Department for dynamic renal scintigraphy which performed after intravenously injection of 0.5 mCi 99m TcDTPA. Scintigraphy was carried out on a Dual Head-Siemens gamma camera using a high resolution collimator. During the dynamic scintigraphy patient was positioned in a supine position. Furosemide, as diuretic stimulator was administered intravenously at 18th minute of the study. Results: The female patient, eight months old, with cough, short breath (dispnea), fatigue, nausea, vomiting and diarrhea was referred to DTPA renal scintigraphy. Symptoms were manifested ten days before patient had undergone the renal scintigraphy. During this time the patient was under pediatrics' control. A patient has undergone the biochemistry, ultrasound and radiologic examinations. Samples were isolated from the urine culture Pseudomonas aureginosa. The patient received antibiotics (Amikacin) for seven days, whereas last five days she received salbutamole and bisolvon. During physical examination we noticed a left abdominal stoma without palpation sensibility associated with an imperforate anus. From DTPA renal scintigraphy we found the absence of a right kidney, malrotation of a left kidney associated with seriously problems during the elimination of urine. Discussion: Unilateral renal agenesis usually is without any major health consequences, but in cases where it is associated with other congenital malformations, such as malrotation of existing kidney, anal atresia and cardiopulmonary anomalies can be very serious problem for life. Conclusion: Dynamic renal scintigraphy is very highly sensitive and helpful method for detection of renal congenital malformations and function abnormalities.