Buildings with spatially complex interiors poise unique challenges during operations and maintenance. A complex interior makes wayfinding difficult, which can inhibit daily occupants from finding their desired location. Additionally, it can hamper emergency responders and evacuations during extreme emergency events. An experiment was conducted to analyze the effects of different information formats and spatial cognition on individual wayfinding in unknown environments. Participants were asked to memorize either a set of two-dimensional (2D) drawings or a three-dimensional (3D) model before navigating through a series of checkpoints in an unfamiliar environment. Individual wayfinding is dependent on an individual’s use of route knowledge or survey knowledge. Route knowledge was assessed from the start of the route to Checkpoint A (i.e., the first checkpoint). Meanwhile, survey knowledge was assessed from Checkpoint A to Checkpoint B. Spatial cognition of participants was measured by administering the card rotation and cube comparison tests. The research found that 3D models have a beneficial impact on the success of individual wayfinding. Furthermore, the success rate of the participants with a low spatial cognition improved significantly when using a 3D model rather than a set of 2D drawings. However, the success rates of participants with a high spatial cognition were not affected by the format of information. While the above results are significant, more experimentation is needed to confirm whether 3D information does effectively lower cognitive demand.