According to Russian researchers, university studies is among the most stressful activities for a person. First-year university students are particularly vulnerable to stress. The use of mindfulness-based programs to help students reduce and manage stress is gaining popularity around the world. Previous research has shown that such programs can improve the psychological well-being of students by reducing levels of anxiety and depression. In addition, students in helping majors, such as psychology students, would greatly benefit from mastering the skills of managing stress, as anxiety and stress are pertinent to their future profession. This pilot case study assesses the effectiveness of a brief mindfulness training aimed at improving Russian students’ mental and physical health. The participants were 83 first-year undergraduate students from the Psychology Department of the Ural Federal University named after B.N. Yeltsin. Data collection was completed in November 2019. A non-randomized controlled trial was conducted using a brief mindfulness training. The results show that the participants in the experimental group demonstrated significantly lower levels of depression (η2 = .07, p = .00) and significantly higher levels of subjective happiness (η2 = .02, p = .02) than participants in the control group. Also, the participants in the experimental group showed marginally significant lower levels of anxiety (η2 = .02, p = .06). Frequent mindfulness meditation practice and the study of theoretical materials were associated with higher rates of psychological well-being of students. The findings suggest that mindfulness training may be an effective tool in addressing psychological challenges experienced by first-year students of the Psychology Department of Ural Federal University.