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High CXCR4 expression correlates with sunitinib poor response in metastatic renal cancer.

The cytopathological diagnosis of metastatic neoplasms to the breast is not always straightforward, especially in the absence of a clinical history of cancer. The usage of improved cytopathological criteria combined with immunocytochemistry may be of great diagnostic help in the identification of breast metastases.

Both clinical and molecular factors are essential to determine prognosis and treatment strategies.