This paper aims to present a review on the main properties of silica (SiO2), such as its water solubility, its structural aspects, as well as its application in industrial and laboratory scales and the use in chromatographic techniques as a stationary phase. Also shown are chemical modifications that may occur on the silica surface and the role of silylating agents in such situations.

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Twelve new 1H-pyrazolo [3,4-b]pyridine phosphoramidate derivatives were synthesized under mild conditions by nucleophilic aromatic substitution reaction of aminoalkylphosphoramidates over 4-Cl substituted pyrazolo [3,4-b]pyridine in good yields. The new compounds were characterized by IR, 1 H, 13 C and 31 P NMR spectroscopy and HRMS. The crystal structure of one compound was solved by X-ray diffraction and showed a network of intermolecular interactions involving phosphoramidate groups.

Synthesis, Crystal Structures, and in silico Toxicity Prediction of Thienopyridine Phosphoramidates. -(PEDROSA, L. F.; DE MACEDO, W. P.; FURTADO, A. C. R.; GUEDES, G. P.; PINHEIRO, L. C. S.; RESENDE, J. A. L. C.; VAZ, M. G. F.; BERNARDINO, A. M. R.; DE SOUZA*, M. C.; Synth. Commun. 43 (2013) 24, 3373-3386, http://dx.

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