Aim: The goal of this study was to determine, for the first time in an east European country, the relationship of 25-hydroxyvitamin D (25(OH)D) serum concentration with extent of coronary artery disease and prognosis in patients with acute coronary syndrome (ACS) during a three-year follow up period. 1-3PAtients And methods: The study included 60 ACS patients hospitalized at cardiology department for ACS between March 2012 and September 2012; and 60 matched controls without ACS. Standard laboratory testing and vitamin D determination were performed in all study patients. In addition, ACS patients underwent coronary angiography and were followed-up for 36 months of ACS for major adverse cardiac events (MACE). ConClusion: There is an association between low serum concentration of 25(OH)D and ACS. Vitamin D level is considerably influenced by diabetes comorbidity. There was no significant association between 25(OH)D and MACE at 36 months in ACS patients.

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Volume 3 • Isse 2 • 1000130length before menarche, suggesting that during puberty, circulating IGF-1 promotes bone periosteal apposition and mass accrual [9].Genetic factors also affect the speed of maturation and growth. Adult height is considered to be a highly heritable and polygenetic trait. Bone mineral density is also highly heritable trait, with as much as 60-80% of variance attributable to genetic factors [21][22][23]. In recent years many studies investigated genetic background of BMD and osteoporosis revealing different genetic markers across the chromosomes [24-27].Previous results indicated the association between genetic markers for IGF-1 gene, gene for estrogen receptor alpha, gene for androgen receptor, aromatase gene [28], vitamin D receptor gene [18], gene for colagen-1 [19] with BMD, bone geometry and osteoporosis. Majority of the research included adults, only recently there is an increased interest in researching genetic determinants of bone metabolism in children [19,20].There are few approaches in measurement of bone mineral density (BMD), but the easiest and ethically more acceptable approach in children is the use of quantitative ultrasound (QUS), a quick, noninvasive and inexpensive method to measure bone strength [21][22][23].

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