In the last few decades, the prevalence of allergodermatoses in European countries, including the Russian Federation, has increased two to three times. The skin barrier plays an essential role in preventing the penetration of allergens and microbial agents into the human body.Atopic dermatitis is one of the most common, genetically determined skin diseases. The development of atopic dermatitis involves environmental factors that violate the skin barrier, as well as genetic, immunological features of the patient.In modern science, the issue of pathogenetic treatment of atopic dermatitis remains not fully resolved. The problem is complicated by the fact that this disease is multifactorial, with the dominance of IgE-mediated allergic reactions, although the level of IgE does not always correlate with the severity of atopic dermatitis.Currently, the development and implementation of genetically engineered drugs for the treatment of this pathology continues, one of such drugs is dupilumab.The article describes the efficacy and safety of the drug dupilumab in the treatment of severe continuously recurrent atopic dermatitis.Keywords: allergodermatoses, atopic dermatitis, severe continuously recurrent course, genetically engineered drugs, dupilumab.