Palavras-chave: Bicarbonato de Sódio; análise físico-química; qualidade.Quality control is a set of activities performed to ensure that the product is not delivered to the consumer without first meeting the defined specifications. This study evaluated the physicochemical quality of sodium bicarbonate, in powdered pharmaceutical form, dispensed in pharmacies in the city of São Luís-MA. Analyzes were performed according to the methods described in the Brazilian Pharmacopoeia 5th edition. Ten samples from the same batch were used from each manufacturer, and three different manufacturers were analyzed, performing identification, purity, weight and assay assays. The samples met pharmacopeic specifications in the identification and purity assays. In the tests for weight determination, the samples analyzed from the three manufacturers fulfill the test with a value found on the average of the results of 100% of the mass in relation to the declared weight, indicating homogeneity in the filling and the supply of the product in the informed quantity. In the assay, the three manufacturers: A (99.73%), B (100.16%) and C (99.94%) were in accordance with the specification of the Brazilian Pharmacopoeia 5th edition. The results show little variation between the units and the average, observed in statistical analysis, suggesting homogeneity between the samples analyzed in the study. It was found that the samples analyzed from the three manufacturers complied with the physicochemical quality tests applied in the study, suggesting to comply with the recommended quality standards.