IntroductionThe study of the psychophysiological response during combat actions has been poorly researched despite its importance for warfighter training and specific instruction. The aim of the present investigation was to analyse the effect of chemical, biological, radiological and nuclear personal protective equipment (PPE) on the psychophysiological response, mechanical and physical load and fine motor skills of professional soldiers in an endurance infantry manoeuvre.Methods16 soldiers conducted an assault manoeuvre with and without the PEE in separate days. We analysed before and after the manoeuvre the psychophysiological response, fine motor skills, shooting test accuracy and anxiety state.ResultsThe use of PPE produced significantly higher (p<0.05) stress, fatigue, temperature, HR, somatic anxiety and time in middle and high HR zones and significantly lower values in speed average and maximum speed. These findings can be used to improve the training and specific instruction for professionals who require the use of PPE equipment.ConclusionThe use of the PPE suit in an assault manoeuvre produces a decrease in the speed of movement, an increase in HR, body temperature, somatic anxiety and subjective perception of effort.

Cutaneous haeangiomas are benign vascular neoplasms that arise from endothelial cells of blood vessels. Haemangiomas account for 0.6%-4% of all equine cutaneous neoplasms and the fetlock is the most commonly affected site. We describe the use of computed tomography angiography (CTA) for the evaluation of a cutaneous haemangioma located on the plantarolateral aspect of the left hindlimb fetlock of a 9month-old Standardbred colt. Computed tomography angiography of the affected fetlock was performed under general anaesthesia. The medial plantar artery was catheterised and a total volume of 50 ml of iodinated nonionic contrast medium (Iopamidol, 300 mg I/ml, Bracco Imaging Canada) was injected at a rate of 2 ml/s. Following contrast medium administration, the dorsal metatarsal artery and branches including the lateral and medial digital arteries were well demarcated. Two smaller lateral and medial arteries were also identified, forming the vascular network of the metatarsophalangeal joint. At the level of the haemangioma, two tortuous arteries arising from the lateral digital artery were identified, in addition to multiple small branches from nearby cutaneous arteries. These vessels supplied the homogeneously strongly contrast-enhancing cutaneous mass. The initial goal of the CTA study was to map the vascular anatomy for arterial embolisation in conjunction with pharmacological therapy. Considering the involvement of multiple small arterial branches, complete surgical excision along with ligation of the two main supplying arteries was alternatively elected, resulting in a successful long-term outcome. Clinical findingsAt the time of second referral to the Ontario Veterinary College at 9 months of age, no abnormalities were observed on physical examination other than recurrence of the proliferative tissues on the plantarolateral aspect of the left metatarsophalangeal joint. The mass was 5.7 cm dorsoplantar 9 3.4 cm proximodistal 9 1.1 cm lateromedial and characterised by a dark purple colour, welldemarcated margins and a combination of verrucous and smooth surfaces (Fig 2). It was easily movable and appeared attached only to the cutaneous and subcutaneous tissues. Pain was not elicited on palpation and no lameness was noted when the colt was evaluated at the trot.

Two green strategies for the copper-catalyzed azide-alkyne cycloaddition reaction (CuAAC) based on two different activation pathways, solvent free mechanochemistry and microwave irradiation (MW) using biomass-derived solvents, are reported for the...

Aims:The durable fluoroacrylate polymer-based sirolimus-eluting stent (Angiolite SES) has shown promising preclinical and clinical results regarding inflammatory vascular reaction and neointimal healing. We aimed to compare performance between the Angiolite SES and an everolimus-eluting stent (EES) in patients with coronary artery disease. Methods and results:The ANGIOLITE trial, a prospective, randomised, multicentre trial, compared the restenosis parameters of both stents in de novo coronary lesions. The primary endpoint was late lumen loss at six-month angiographic follow-up. In-stent healing was assessed by optical coherence tomography (OCT). The main clinical endpoint was target lesion failure (TLF) evaluated up to 24 months. A total of 223 patients were randomised 1:1 to EES or SES. At six months, in-stent late lumen loss was 0.08 mm (±0.38) for EES vs 0.04 mm (±0.39) for SES (difference=-0.04 mm, 95% CI: -0.15, 0.07, p for non-inferiority=0.002). By OCT, the rate of uncovered to total number of struts score >30% was comparable between the groups whereas neointimal thickness was reduced in the SES arm (9.0% [7.6, 10.6] vs 9.9% [8.5, 11.3], p=0.41; and 86.4 [81.6, 91.2] µm vs 72.1 [68.2, 76.0] µm, p<0.01, respectively). At 24 months, TLF occurred in eight patients (7.6% [3.3, 14.5]) in the EES arm and in seven patients (7.1% [2.9, 14.0]) in the SES arm (p=0.88). The definite/probable stent thrombosis rate was comparable between the groups (1.9% [0.2, 6.7] vs 1.0% [0.0, 5.5] EES vs SES, respectively; p=0.59). Conclusions:This trial demonstrates similar antirestenotic efficacy at midterm follow-up of the Angiolite SES vs an EES. Clinical endpoints were comparable between the groups at two-year follow-up.

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