This study evaluated the effect of a partly fermented infant formula (using the bacterial strains Bifidobacterium breve C50 and Streptococcus thermophilus 065) with a specific prebiotic mixture (short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS; 9:1)) on the incidence of gastrointestinal symptoms, stool characteristics, sleeping and crying behaviour, growth adequacy and safety. Two-hundred infants ≤28 days of age were assigned either to experimental infant formula containing 30% fermented formula and 0.8 g/100 mL scGOS/lcFOS or to non-fermented control infant formula without scGOS/lcFOS. A group of breastfed infants served as a reference. No relevant differences in parent-reported gastrointestinal symptoms were observed. Stool consistency was softer in the experimental versus control group with values closer to the breastfed reference group. Daily weight gain was equivalent for both formula groups (0.5 SD margins) with growth outcomes close to breastfed infants. No clinically relevant differences in adverse events were observed, apart from a lower investigator-reported prevalence of infantile colic in the experimental versus control group (1.1% vs. 8.7%; p < 0.02). Both study formulae are well-tolerated, support an adequate infant growth and are safe for use in healthy term infants. Compared to the control formula, the partly fermented formula with prebiotics induces stool consistencies closer to breastfed infants.

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Abstract. Cloud computing is one of the biggest trends in information technology, with individuals, companies and even governments moving towards their use to save costs and increase flexibility. Cloud infrastructures are typically based on virtualised environments, to allow physical infrastructure to be shared by multiple end users. These infrastructures can be very large and complex, with many end users, making their configuration difficult, error-prone and timeconsuming. At the same time, the fact that diverse end users share the same physical infrastructure raises security concerns, and can lead to a significant impact from misconfiguration or being slow to react to attacks. In this paper, we focus on the use of Policy Based Management techniques to manage cloud infrastructure, identifying the requirements, surveying the state-of-the-art, identifying the challenges and proposing potential solutions.