Vehicle routing (VR) is critical in successful logistics execution. The emergence of technologies and information systems allowing for seamless mobile and wireless connectivity between delivery vehicles and distribution facilities is paving the way for innovative approaches to real-time VR and distribution management. This paper investigates avenues for building upon recent trends in VR-related research towards an integrated approach to real-time distribution management. A review of the advances to-date in both fields, i.e. the relevant research in the VR problem and the advances in mobile technologies, forms the basis of this investigation. Further to setting requirements, we propose a system architecture for urban distribution and real-time event-driven vehicle management.

Summary During neuronal development, local mRNA translation is required for axon guidance and synaptogenesis, and dysregulation of this process contributes to multiple neurodevelopmental and cognitive disorders. However, regulation of local protein synthesis in developing axons remains poorly understood. Here, we uncover a novel role for the actin-regulatory protein Mena in the formation of a ribonucleoprotein complex that involves the RNA-binding proteins HnrnpK, and PCBP1, and regulates local translation of specific mRNAs in developing axons. We find that translation of dyrk1a, a Down Syndrome- and Autism Spectrum Disorders- related gene, is dependent on Mena, both in steady state conditions as well as upon BDNF stimulation. We identify hundreds of additional mRNAs that associate with the Mena complex, suggesting it plays broader role(s) in post-transcriptional gene regulation. Our work establishes a dual role for Mena in neurons, providing a potential link between regulation of actin dynamics and local translation.

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