INTRODUCTION: Continuous Professional Development (CPD) offers nurses the opportunity to improve their knowledge, skills, and also improve their performance in the healthcare setting. The purpose of the study was to examine if there is a relationship between CPD and job performance and to find if there is a significant difference of job performance when sex, age, and clinical experience are considered.  METHOD: Correlational research design was utilized; 164 registered nurses were conveniently sampled from Ghana. The study utilized a self-constructed survey questionnaire for continuous professional development while Six Dimension Scale of Nursing Performance (SDNS) developed by Schwirian (1978) was adopted and modified to measure the job performance of nurses. The statistical treatments used were Pearson Correlation, t-test, and ANOVA to address the research questions. RESULTS: The study showed that there was a moderate positive significant relationship between continuous professional development and job performance. There was no significant difference in job performance when age, sex, and clinical experience are considered.  DISCUSSION AND RECOMMENDATION: Healthcare administrators should encourage and advocate for the participation of nurses in continuous learning to improve nurses’ knowledge and skills. Institution policies should be properly aligned to help nurses in the participation of professional roles. Further research should explore other variables in relation to continuous professional development to improve the job performance of nurses.