IMPORTANCEWomen with recent gestational diabetes (GDM) have increased risk of developing type 2 diabetes. OBJECTIVE To investigate whether a resource-appropriate and context-appropriate lifestyle intervention could prevent glycemic deterioration among women with recent GDM in South Asia. DESIGN, SETTING, AND PARTICIPANTS This randomized, participant-unblinded controlled trial investigated a 12-month lifestyle intervention vs usual care at 19 urban hospitals in India, Sri Lanka, and Bangladesh. Participants included women with recent diagnosis of GDM who did not have type 2 diabetes at an oral glucose tolerance test (OGTT) 3 to 18 months postpartum. They were enrolled

The present research work was to formulate and evaluate the site specific delivery of aceclofenac niosomes in order to overcome the problem of GI discomfort and to produce a better therapeutic response. Niosomes of Aceclofenac were formulated by an Ether injection method using different concentrations of drug, cholesterol and surfactant (Span 60). The formulations were evaluated from the various methods like vesicle shape, particle size, entrapment efficiency, drug content, compatibility studies and in-vitro drug release. Ether injection method was found to be most satisfactory with respective to niosomes particle size, drug entrapment efficiency, in-vitro drug release and its release mechanism was followed by krosmeyer Peppas method R2 =0.9840.

In the present research work mixed hydrotropic solubilization phenomenon is used to enhance the solubilization of poorly water soluble drugs. Bulk drug samples were identified by the observed IR spectra and the melting points determination. Sodium benzoate, niacinamide and urea are the hydrotropes were selected for the solubility enhancement of drugs Solubility enhancement ratios for selected poorly water-soluble drugs were determined. Results showed that remarkable increase in aqueous solubility of Miconazole in presence of large concentration of hydrotropes. Marketed Miconazole tablets determined by spectrophotometric analysis using hydrotropic solubilization techniques. Validation of the proposed analysis methods is confirmed by satisfactorily low values of statistical parameters viz., standard deviation, percent coefficient of variation and standard error.