A -Study Design, B -Data Collec on, C -Sta s cal Analysis, D -Data Interpreta on, E -Manuscript Prepara on, F -Literature Search, G -Funds Collec on Background. Health-related quality of life (HRQoL) is an important component of comprehensive management in primary care. Objec ves. The purpose of this study was to inves gate the rela onships between physical performance measures and self-reported HRQoL and to fi nd op mal values of muscle func on tests associated with lower HRQoL. Material and methods. From a single primary health care center pa ent list, 330 subjects were randomly selected. Informa on about the pa ent's age, gender, body mass index and presence of self-reported chronic diseases was collected, as well as analyses for systemic infl amma on and vitamin D. Physical performance was measured by dominant hand grip strength (GS) and a 30-second chair stand test (30-CST). The physical (PCS) and mental (MCS) component scores of the Short-Form-36 Ques onnaire (SF-36) were used to evaluate HRQoL. The predic ve power of physical func on measures were tested with mul variate linear regression analyses. Threshold values for physical func on tests were calculated by receiver opera ng characteris c curves.