Natural remedies are more acceptable in the belief that they are safer with fewer side effects than the synthetic ones. Herbal formulations have growing demand in the world market. The present work deals with the development & evaluation of the herbal anti-acne face wash containing aqueous extract of Luffa cylindrica seed oil, neem leaves (Azadirachta indica), Pumpkin. Although various topical herbal formulations for acne are available in the market, we propose to make pure herbal formulation without using any synthetic soap . The plants have been reported in literature having good anti-microbial, anti-oxidant & anti-inflammatory activity also and saponins present in the Luffa cylindrica seeds used as a base to form the soap. Prepared formulations were evaluated for various parameters like colour, appearance, consistency, washability, pH & spreadability. The formulation was compared with the marketed preparation.

Solid dispersion is one of the mostly discussed but still remained as a challenging aspect for improving dissolution rate and hence bioavailability of a poorly water soluble drugs. The focus of this review is to highlight technology and various approaches for the preparation of solid dispersion, materials used various advantages, disadvantages and future prospects with its pharmaceutical applications. This article also focuses the use of factorial design along with its types, uses and applications for the optimization of solid dispersion formulation.

Introduction:- Capecitabine resealed erythrocytes were prepared as a potential targeted drug delivery system for the treatment of hepatocellular carcinoma. This system has been developed to increase the therapeutic efficacy of drug and to reduce its adverse effects. This paper demonstrated the acute toxicity study of the formulation in Swiss albino mice. Methodology:- Dose of Capecitabine was 2000 mg/kg orally with zero toxicity as per the previous studies. The doses of formulation selected were 1/5th, 1/10th, 1/20th of the oral dose calculated on the basis of the % encapsulation efficiency of drug in formulation. The doses were given intravenously in single dose in mice tail vein. All the animals were observed for 14 days period for mortality, behavioral symptoms and locomotor activity. Results:- After sacrification of animals, serum was collected to analyze hematological and biochemical parameters. The isolated liver was observed for histopathological changes in mice. Here, we found that all the three to be selected would be safe for further in- vivo screening of Hepatocellular carcinoma. Conclusion:- So, we concluded that, all the three doses of formulation low (0.90mg/kg), medium (1.79mg/kg) and high (3.58mg/kg) with no signs of mortality, behavioural changes and no necrosis in liver histopathology. This revealed that, all the three selected doses were safe for further in vivo studies.