Currently diabetes mellitus (DM) is a worldwide problem linked to hyper-glyce¬mia and has affected people both in developing and developed countries. DM is divided into Type 1 (T1DM) and Type 2 (T2DM). Moreover, the T2DM is the most prevalence form that encompasses a reduce responsiveness to insulin-sensitive cells or defects in insulin secretion. Exposure to chronic immobilization stress contributes to the development of hyperglycemia and hyperlipidemia that can lead to cardiovascular complications. Herbs with hypoglycemic properties, especially Origanum vulgare L., would be useful in hyperglycemia treatment. Oral administration of aqueous extract showed significant effect on hyperglycemia and improving glucose tolerance. In addition, extract of O. vulgare reduced total cholesterol, low-density lipoprotein cholesterol levels, and vice versa increased high-density lipoprotein cholesterol levels, and also decreased liver enzymes levels (alanine aminotransferase and aspartate aminotransferase) compared with untreated group and might be recommended as herbal remedy in the treatment of stress-induced hyperglycemia.