BACKGROUND Not only analgesia, muscle relaxation is also part of balanced anaesthesia. An ideal muscle relaxant for continuous infusion should have low potency, rapid onset, short duration of action, without any cumulative effect and, should be easily reversible with proper antagonists. Vecuronium and Atracurium are two muscle relaxants that come close to fulfil most of the above criteria. Neuromuscular monitoring reduces the incidence of residual block and should be part of standard monitoring equipment. The train-of-four (TOF) count appears to be the method of choice. We wanted to compare intraoperative muscle relaxation and neuromuscular recovery after continuous infusion of vecuronium and atracurium using train-of-four. METHODS The comparative study was done in 40 patients aged 18-60 years undergoing craniotomies with ASA Grade I and II. 40 patients were divided into two groups, 20 in each group. Group V received Vecuronium with loading dose of 0.1 mg/kg and after appearance of TOF COUNT 1, infusion started at a rate 0.8 mcg/kg/min. Group A received Atracurium loading dose of 0.5 mg/kg and infusion started at a rate of 412 mcg/kg/min. After stopping the infusion at the end of surgery, time for TOF COUNT 3 was noted. RESULTS Intra operative haemodynamics were stable for Vecuronium compared to Atracurium. Mean Recovery Time for a duration of infusion of about 3-4 hrs were noted for both groups. Then for Vecuronium, the mean recovery time was 62.63 ± 23.6 min and for Atracurium, it was only 26.8 ± 10.8 min., respectively. CONCLUSIONS Time for intubation did not show significant difference between the two groups. The rate of infusion was more for the Atracurium group as compared to Vecuronium group because of quicker spontaneous recovery. Combination of Continuous Infusion of Atracurium or Vecuronium, monitored by TOF count, use of anticholinesterase drugs, permits safe and successful recovery. It was concluded that Vecuronium produced more haemodynamic stability compared to Atracurium but there is slower spontaneous recovery of residual neuromuscular blockade than with Atracurium.