The influence of Coriolis body force, electro-magnetohydrodynamics (EMHD) and thermal radiative heat transfer on the Casson hybrid mixed convection nanofluid driven by an exponentially accelerated plate adjacent to a porous medium in a rotating system is analyzed. Hybrid (Ag-Al2O3) and Al2O3 nanofluids are considered with ethylene glycol (EG) base fluid. The Maxwell-Garnett model has been deployed to derive the thermal conductivity of the hybrid nanofluid. The electrical potential problem is simplified by applying Debye-Hückel linearization. The Laplace transform method (LTM) is employed to derive closed-form solutions. In terms of heat transfer, the hybrid nanofluid (Ag-Al2O3)/EG and nanofluid (Al2O3)/EG performance are compared. The benefits of EG-based hybrid nanofluid (Ag-Al2O3) relative to EG based (Al2O3) nanofluid, are elaborated. The analysis finds applications in centrifugal dynamic electrochromatography under electromagnetic gradient, bio-analytical separation techniques with electric field gradients and rotary bio-inspired DC electromagnetic blood pumps.