Introduction: Rational use of corticosteroids is very important in the long term for improving patient safety. The main objective of the study was to analyze the prescribing patterns of steroids in a district general hospital, Amravati. Materials and methods: A prospective observational study was carried out over a period of six months in a district general hospital. All patients receiving any category of steroid therapy were enrolled, and the prescribing tapering patterns of steroids were reviewed. The demographic data, disease data and data on the utilization of various steroids were analyzed, and the knowledge of the patients was assessed by using a Michigan questionnaire. Results and discussion: 179 patients were recruited for the study. Steroids were prescribed for various (29.6%) respiratory conditions, (10.1%) CVS diseases, (11.7%) CNS, (1.6%) in hepatic disorders, (1.1%) musculoskeletal disorders, (3.4%) skeletal disorders, (0.6%) renal impairments, (3.9%) GI disorders, (19.0%) skin diseases and (19.0%) other diseases. The utilization of steroid dexamethasone was the most commonly prescribed to 111 patients (63.8%) followed by hydrocortisone (57 patients, 32.8%) and prednisolone (6 patients, 3.4 %). Dexamethasone was most commonly associated with adverse effects (1.8% of such as headaches, abdominal pains, and rashes), followed by prednisolone (0.8% of such as facial swelling), clobetasol (0.4%) and fluticasone (0.4 %). Conclusions: Very little variation was found in the prescription pattern amongst the healthcare professionals. Most of the drugs were prescribed rationally; the significance of the study is to improve the patient safety in the long-term use of steroid therapy by observing the prescribing patterns as irrational use of steroids can increase the risk of adverse effects.

The liver assumes a significant part in keeping up with the metabolic capacity and discharge of poisons from the body. A physical issue or liver brokenness brought about by the utilization of poisonous synthetics, over-the-top liquor and microorganisms bring about a difficult condition called hepatotoxicity. Madhuca longifolia having a place with Sapotaceae family is found to have pharmacological properties in the treatment of different disorders. Madhuca longifolia is likewise considered a therapeutic tree also, is helpful for outside application in treating skin infections, stiffness, migraine, persistent clogging, heaps, hemorrhoids, and ethno clinical properties like antibacterial, anxiolytic qualities, anticancer, hepatoprotective, antiulcer, antihyperglycemic, pain-relieving exercises, and so on. Leaves of mahua are utilized in the treatment of dermatitis, wound mending, anti-burn, bone crack, anthelminthic, emollient, skin illness, stiffness, and cerebral pain. The flowers are used as a tonic, pain-relieving, and diuretic; bark for an ailment, persistent bronchitis, and diabetes mellitus and leaves as an expectorant and constant bronchitis and Cushing's sickness. In this review we make a compilation focused on the synonyms, botanical description, phytochemicals, pharmacological activity, and medicinal uses of Madhuca longifolia.

Background: The primary goal of developing the antifungal nail lacquer is to determine its suitability for delivering medicine to the desired location. Because the area between the nail and the skin is commonly impacted, topical treatment is difficult to reach. Statistical techniques were used in this study to understand the source of variables. Methods: Nail lacquer formulations were prepared using luliconazole using a simple mixing method. The drug's permeability was made better by using the permeation enhancers in different amounts. Results: The drug-excipient study revealed no physical or chemical interaction, while the standard calibration curve showed that the drug follows Beers-Lamberts' law with a coefficient value of 0.984. The medicated nail lacquer was evaluated for various parameters such as non-volatile content, which was in the range of 37.020.72-43.050.57%, drying time was found to be in the range of 42-97 seconds, water resistance was found to be 0.10-0.24gm, the drug content in the prepared nail paint was found to be in the range of 94.331.52-98.33.51%, and the drug release study revealed the drug release in the range of 0.70.1-51.580.28%, which shows satisfactory results. The antifungal study revealed a zone of inhibition for the prepared nail paint of 47 mm, which was the highest among all the formulations and also the highest among the studies conducted with pure drug and control formulation. The stability study revealed that the optimised formulation, i.e., F2, was stable during the time span of the study, and hence it was concluded that the prepared formulation was stable. Conclusion: From the results above, it can be concluded that nail lacquer containing luliconazole could be a promising drug delivery system for treating fungal nail infections.

Tobramycin is another aminoglycoside anti-microbial with a wide antibacterial range in vitro, and pharmacokinetic properties like those for gentamicin. Tobramycin is more dynamic than gentamicin against Pseudomonas aeruginosa and dynamic against numerous gentamicin safe strains, yet isn't dynamic against enterobacteriaceae impervious to gentamicin. Hypothetically, tobramycin enjoys an upper hand over gentamicin against diseases brought about by P. aeruginosa, yet any benefit in clinical practice presently can't seem to be enough illustrated. Clinical involvement in tobramycin is significantly not exactly with gentamicin. While tobramycin seems to offer no unmistakable benefits over gentamicin against touchy organic entities it is shown in contamination brought about by strains of P. aeruginosa which are impervious to gentamicin, yet touchy to tobramycin. Like gentamicin, tobramycin acts synergistically with carbenicillin and the cephalosporins. The viability of the tobramycin-carbenicillin blend has been displayed in endocarditis brought about by P. aeruginosa which was lethargic to gentamicin in addition to carbenicillin. Ototoxicity and nephrotoxicity like that seen with other aminoglycosides have been experienced in helpful preliminaries with tobramycin and more extensive clinical experience is important to decide the general occurrence of these incidental effects with gentamicin and tobramycin utilized under comparable conditions. Antimicrobial movement: In relative examinations, in vitro, tobramycin is more dynamic than gentamicin against clinical separates of Pseudomonas aeruginosa. Likewise, the inhibitory file, which is the proportion between the serum fixations accomplished at common remedial portions and the base inhibitory focus, for Pseudomonas aeruginosa is higher for tobramycin than for gentamicin.

In the present experiment, Tricholepis glaberrima DC has been taken to study its antidepressant activity. The study was carried out in two different doses of the test drug. The animals were divided into 4 groups of 5 animals each, respectively. Mice in Group I (control) and II (standard) were administered distilled water, per oral and Imipramine 10mg/kg, per oral once respectively. Group III and IV were treated with the test drug METG in the dose of 100mg/kg and 300mg/kg, respectively. Findings of the test groups were compared with that of standard as well as plain control groups. In despair swim test and Tail suspension method, METG (100mg/kg and 300mg/kg per oral) depicted significant (*p<0.05 and p<0.01) results, in a dose dependent manner, when compared to vehicle treated group, indicating significant antidepressant activity. The results obtained in the present study for antioxidant activity indicate that the plants of Tricholepis glaberrima DC are a significant source of natural antioxidants. This test reveals the antidepressant activity of Tricholepis glaberrima DC Via serotonergic, adrenergic mechanism in a dose dependent pattern.