Background Nurses experienced physical and mental exhaustion during the COVID‐19 pandemic. Understanding the impact of the pandemic on nurses and effective strategies to support them is critical for increasing nurse resilience and reducing burnout. Aims The aims of this study were (1) to synthesize the literature examining how factors associated with the COVID‐19 pandemic affected the well‐being and safety of nurses (2) and to review interventions which may promote nurse mental health during crises. Methods Using an integrative review approach, a comprehensive search of the literature was conducted in March 2022 using the following databases: PubMed, CINAHL, Scopus, and Cochrane. We included quantitative, qualitative, and mixed‐method primary research articles published in English in peer‐reviewed journals from March 2020 through February 2021. Included articles focused on nurses caring for COVID‐19 patients and addressed psychological factors, supportive hospital leadership strategies, or interventions to support well‐being. Studies were excluded if they focused on professions outside of nursing. Included articles were summarized and appraised for quality. Findings were synthesized using content analysis. Results Of the 130 articles initially identified, 17 were included. Articles were quantitative (n = 11), qualitative (n = 5), and mixed methods (n = 1). Three themes were identified: (1) loss of life, hope, and professional identity; (2) lack of visible and supportive leadership; and (3) insufficient planning and response. These experiences contributed to increased symptoms of anxiety, stress, depression, and moral distress in nurses.