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Adverse effects of lidocaine therapy for proved or suspected myocardial infarction were evaluated for 48 hours in 285 patients arriving at the hospital within 6 hours of the onset of chest pain. More adverse effects occurred in patients receiving lidocaine (51%) than in those receiving placebo (16%; P < 0.0001).Patients receiving lidocaine had more adverse effects in the first 12 hours as compared with the second 12 hours (50% vs. 19%; P < 0.001). Patients without infarction who received lidocaine had more adverse

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