Many frail older adults are slim, weak and under nourished; this part of frailty remains a critical concern in the old age. However, there is also strong conformation that excessive obesity contributes to frailty, therefore, present study was conducted to assess the Relationship between Obesity and Frailty in Older Population of Karachi, Pakistan. A cross sectional survey was conducted in different hospitals of Karachi, Pakistan from January to March 2018. BMI was measured by standard procedure in already diagnosed 377 patients of Fraility (mild and sever) and SPSS version 23 was used to analyze the data. The majority were (n=215, 57%) male and having age between 61 to 63 years (n=75, 19.9%), overweight (n=151, 40%) and Obese were (n=37, 9.8%) no significant correlation was found between obesity and frailty. This Study concluded that there is no significance of obesity on Fraility, because mostly the government facilities are being attended by the poor patients and the rich patients who may have the obesity along with Fraility may go to the private institutes.

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Objectives: The main objective of the study is to identify, assess and categorize the severity and causality of adverse drug reactions (ADRs) and to analyze the management techniques to prevent them. MethOds: This is a prospective observational study done for one year at the inpatient department of a tertiary care hospital, Hanamkonda. Patients who visited the hospital with different diseases were reviewed on a daily basis and monitored for ADRs. The Patients' data was collected from various sources and documented in a data collection form. Suspected ADRs were assessed by using WHO scale, Karch and Lasagna scale, Naranjo's scale and severity assessment was done using Modified Hartwig and Siegel scale. Results: A total of 2500 patients were reviewed, of which 120 (4.8%) patients met the study criteria of having at-least one ADR. Among 120 patients, 143 ADRs were found with a higher incidence among females 80 (56%) than males 63(44%). Among 143 ADRs, 59(41.25%) gastrointestinal reactions were more frequently reported than the others. The pattern of drugs causing these ADRs showed drugs of different classes varying from the highest being Antiplatelets-aspitin+clopidogrel {13(11%)} and Anti-cancer drugs-cisplatin {12(10%)} to the least being Penicillins' and LMW Heparin{2(2%)}. On evaluation of the causality of ADRs, a majority of them were found to have a 'possible 'and 'probable' association with the suspected drugs. Majority of the ADRs were 'moderate' in severity. cOnclusiOns: Having identified and assessed the causality and severity of these ADRs, it was found that majority of reactions were moderate, showed probable association with the drugs and found to be more in patients experiencing gastrointestinal disease condition than the others. The methods of management based on the pattern of drugs causing the ADRs are monitoring signs and symptoms, caution, contraindications, monitor serum concentrations, dosage adjustment, alternate drug, discontinuation, and limited use. PHP54 CHroniC Patients attitudes, Beliefs, and exPerienCes regarding PolyPHarmaCy and Willingness to dePresCriBe in Quetta

Objectives: To examine demographic and socioeconomic factors associated with hospitalizations due to mental disorders among Asians in the Kansas City metropolis (Missouri, U.S.) from 2004 to 2013. MethOds: This was a retrospective study using the Missouri Hospital Discharge Data and American Community Survey. Mental disorders were identified by ICD-9 codes 290.0-290.9, 292.0-302.9, and 305.1-319.9. Missouri Hospital Discharge Data provided hospitalizations (yes/no) due to mental disorders according to zip codes. American Community Survey provided median annual income (< $50,000 or ≥ $50,000), proportion of high school graduates or higher (< 30% or ≥ 30%), proportion of those who were foreign born (< 1% or ≥ 1%), proportion of those who were unemployed (< 5% or ≥ 5%), sex, and age (< 65 or ≥ 65 years old) according to zip codes. The zip codes of nine counties in the Kansas City metropolis were included. A multiple logistic regression was conducted, in which hospitalization was the dependent variable, and the other variables were independent variables. Results: Asians had 10,780 hospitalizations due to all causes and 366 hospitalizations due to mental disorders from 2004 to 2013. Asians had a higher rate of hospitalizations due to mental disorders, 194 per 100,000, compared

Objective: This study aimed to assess the knowledge and awareness regarding cervical cancer and its prevention among nurses working in different hospitals of Quetta, Pakistan. Methodology: The cross sectional, descriptive study was conducted by using structured questionnaire in different hospitals of Quetta from January to September 2016. Convenient sampling technique was applied by targeting all the nurses working in different hospitals of Quetta city. Study questionnaire was developed and tested for validity and reliability. Descriptive and inferential statistics (Mann Whitney U test and Kruskal Wallis tests, p<0.05) were used to assess the significance among study variables and were performed by using IBM SPSS v.20. Results: Out of 415 distributed questionnaires 324 were returned (response rate of 78%). The mean Age of respondents was 28.18 ±9.5 years. Majority (n=127, 43.3%) of participants were interns and had no or less than one year of experience (n=128, 43.7%) with negative family history of any cancer (n=275, 93.9%). Mean knowledge score was 18.52±4.84with majority (n=258, 88.1%) had adequate knowledge regarding cervical cancer. Respondent sage, current area of practice, qualification, Institute of degree and past family history were contributing factors (p > 0.05) in adequate knowledge in this study. The results also reviled that not only 68.3% (n=200) and 65.5% (n=192) respondents knew that cervical cancer is vaccine preventable and availability of the vaccine for it. Conclusions: Nurses working in different hospitals of Quetta city had better understanding of the disease cervical cancer and its prevention. Yet many of the respondent are not aware of it vaccine and its availability.