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Background: Anxiety is an unpleasant state of feeling agitation and pressure induced by the patient's fear of hospitalization, anesthesia or surgery. Objectives: The present study is aimed to compare the effects of dried extract of saffron and diazepam on soothing the preherniorrhaphy surgery anxiety. Patients and Methods:In this double blind clinical study, during 8 months, 102 patients were studied in 2012. all the patients in intervention group (n = 50) received 25 mg dried extract of saffron and participants in control group (n = 52) received 5 mg oral diazepam. Level of anxiety of the patients was measured using speillberger state-trait anxiety inventory (STAI) before intervention and 3 hours after administration (immediately after entering the surgery room) filled out by the patients. The patients in the two groups were compared concerning level of anxiety before/after intervention. The two groups of participants had almost equal demographic features.

Objective:To assess the effectiveness of laryngeal mask airway, endotracheal tube and oropharyngeal airway for airway management in prehospital emergency care.Methods:The study sample of this randomized clinical trial was 54 patients needing pre-hospital airway management. All cases of intubation (ETI); after two failed attempts (37 patients), were randomly assigned to the oropharyngeal airway (OPA), and the laryngeal mask airway (LMA) groups. Patients’ hemodynamic, SaO2 and airway management parameters, were compared in three groups. The study data were analyzed by the Chi-square and one-way ANOVA, Bonferroni post-hoc, using SPSS, v. 18.0.Results:The results demonstrated that before and after the study, there was no significant difference among the study groups in terms of hemodynamic variables (P > 0.05) expect SaO2 (P < 0.001). The results also revealed that in the ETI group (n=17), the number of attempts and the time spent on inserting the airway device was significantly more than other two groups (P < 0.05).Conclusion:Laryngeal mask airway is as effective as oropharyngial airway for pre-hospital airway management by paramedics.

Aims: To reduce discomfort and anxiety, providing true sedation for the patients hospitalized in ICU is very important. Therefore, the staff of ICU needs tools to measure effective sedation in the patients. The aim of this study was to assess the sedation status in the patients hospitalized in ICU via Sedation-Agitation Scale (SAS) and to compare the findings with Visual Analog Scale (VAS). Instrument & Methods: In this correlational study in 2015, 106 patients hospitalized in the intensive care units of Qaem Hospital of Mashhad, Iran, were selected via quota sampling method and studied. Sedation status of the patients was assessed by the validated Persian version of SAS and VAS. Data was analyzed by SPSS 20 software and Spearman's correlation coefficient test. Findings: There was a positive and significant correlation between SAS and VAS (p<0.001; r=0.824). The highest scoring of SAS, which was 6, was equivalent to score 3 in VAS. In general, the higher the score of SAS, the higher the score of VAS was. Conclusion: SAS and VAS are in a high correlation to assess sedation. Therefore, SAS can be used as a valid tool in the treatment sector.

Aims: Endotracheal intubation is an invasive technique which is associated with severe cardiovascular complications. This study aimed to compare the effects of lidocaine 10% spray on the laryngoscope blade with intravenous lidocaine on cardiovascular responses to laryngoscopy and intubation in elective surgical patients. Materials & Methods: In this clinical trial that is performed in 2013, 90 candidates of elective surgery in Gonobad City, Iran hospitals were randomly divided to three groups; control (no drugs were used), intravenous lidocaine (three minutes before laryngoscopy) and lidocaine 10% (just before laryngoscopy). Heart rate and systolic blood pressure, diastolic blood pressure and mean arterial blood pressure were recorded immediately before, immediately after, and 1, 3 and 5min after laryngoscopy. Data were analyzed using SPSS 20 by repeated ANOVA and Tukey post hoc tests. Findings: There were significant differences in systolic, diastolic and mean arterial blood pressure between control group and each intravenous lidocaine and lidocaine 10% groups after laryngoscopy (p<0.001). There was no significant difference in any of the three variables between intravenous and spray groups. No significant difference was found between the three groups in heart rate (p=0.16). Conclusion: Compared with intravenous lidocaine administration, lidocaine 10% spray on the laryngoscope blade lead to better stability in blood pressure after laryngoscopy, but has no effect on the heart rate.