We report a straightforward route for the synthesis of a novel functional polymer bearing ionic liquid as an efficient and green acidic catalyst for the preparation of bisamides.

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Groebke-Blackburn-Bienayme reaction has been utilized for the synthesis of new imidazo[1,2-a]pyrimidine derivatives as novel anticancer agents. The cytotoxic activities of compounds were evaluated against human cancer cell lines including MCF-7, T-47D, and MDA-MB-231, compared with etoposide as the standard drug. Among the tested compounds, hydroxy- and/or methoxy-phenyl derivatives (6a-c and 6k) with IC values of 6.72-14.36 μm were more potent than etoposide against all cell lines. The acridine orange/ethidium bromide double staining and DNA fragmentation studies demonstrated that the cytotoxic effect of 3-hydroxy-4-methoxyphenyl derivative 6c is associated with apoptosis in cancer cells.

A heterogeneous reaction-based colorimetric chemodosimeter toward cyanide anions was designed based on a hybrid pyrylium/alumina probe which possesses a great selectivity for CN(-) over other common anions even at significantly higher concentrations. The synergistic incorporation of the inorganic matrix and the organic receptor can play a pivotal role in the convenient field-usable determination of this toxic anion in water. Moreover, the catalytic properties coming from the inorganic matrix can greatly amplify the sensor performance.

A novel heterogeneous copper catalyst based on a 3D-network polymer containing pendant amine groups was synthesized via post-functionalization of the polymeric backbone followed by incorporation of copper(i) ions.