In their review, Arslan et al[1] did not describe the status of Helicobacter pylori (H. pylori) treatment with furazolidone and the resistance to this antibiotic. We have presented different surveys showing the resistance of H. pylori to furazolidone from Asia and South America. The resistance rates varied but were mostly low (< 5%). There are not enough data on its efficacy and resistance in the United States and Europe. H. pylori mutations occurring in the oorD gene, including A041G, A122G, C349A(G), A78G, A112G, A335G, C156T and C165T, and in the porD gene, including G353A, A356G, C357T, C347T, C347G and C346A, have been indicated to be possibly related to the observed resistance. Additionally, to complete Arslan et al’s statement regarding levofloxacin resistance, it should be noted that compound mutations of N87A, A88N and V65I at codon Asn-87 were recently observed in the gyrA gene for the first time. However, the results on these topics are not sufficient, and more worldwide studies are suggested.

Iron is a fundamental micro-element in body. Iron defi ciency is the most prevalent nutritional defi ciency around world. Iron defi ciency can disarrange physical growth and neurocognitive development of children thorough different ways such as decreasing oxygen transport capacity, decreasing energy production and decreasing the appetite. The aim of this study was to evaluate iron defi ciency prevalence in children between 6-18months old in Babol, Iran. This cross sectional study was performed on 100 children and adolescents with growth retardation in Babol. Weight and height of children was measured and comparing with the growth curve indices, Hb and mid MCV of children in percentile Height and weight lesser than 3 was evaluated. In this study, prevalence of anemia in growth retarded children was 35.9% whereas prevalence of microcytic anemia was 20% followed by iron defi ciency prevalence of 1.6% and 25%. Average of ferritin level decreased with increasing of severity of growth disorder in children. The results of this study suggest that treatment of growth retarded children with iron supplements can improve their growth. Because data about prevalence of IDA in Iranian children is limited, we suggest further studies to be performed to defi ne an average range of iron concentrations in accordance with other micro-elements such as zinc and copper in children of this area.

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