Purpose: Gloriosa superba Linn (liliaceae)

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Gloriosa superba Linn. is used as a folk remedy for abortion. In the present study, ether, chloroform, and ethyl alcohol extracts of roots of Gloriosa superba Linn. were evaluated for the antifertility activity in female Wistar albino rats. Toxicity studies were carried out in mice. Phytochemical analysis of different extracts shows the presence of carbohydrates, flavonoids, steroids, alkaloids, tannins and glycosides. All extracts were safe at a dose of 175 mg/kg body weight. The antifertility activity results show a significant reduction in number of implants (p<0.001) and number of pups born (p<0.0001) in all groups of different extracts (20mg/kg and 40mg/kg) compared to control. Ethyl alcohol (EyGS), chloroform (CEGS) and ether (ErGS) extracts of roots of Gloriosa superba Linn have shown 33.33%, 50%, 66.66% reduction in the pregnancies respectively compared to control. All the extracts have shown statistically significant (p< 0.0001) abortifacient activity compared to control.

Background The rhizome extract of Gloriosa superba Linn family Liliaceae is known to induce labor and facilitate normal delivery.Objective The present study was undertaken to assess the effect of ethanolic extract of Gloriosa superba Linn EyGS roots on the reproductive system of female Wistar rats.Material and Methods Immature ovariectomized OVX Wistar rats were administered EyGS orally at 20 and 40 mgkg body weight. Uterotrophic assay was performed to evaluate the effect of EyGS on estrogenic and progestogenic activity. The parameters evaluated were number of cornified cells in the vagina uterine weight and decidual weight. Biochemical parameters histopathology of the uterus and in vitro uterotonic activity were also assessed.Results Analysis of the effect of EyGS on vaginal cornification and deciduoma formation demonstrated vaginal opening without cornified cells decrease in uterine weight proliferation of uterus and reduction in deciduoma formation. EyGS produced decrease in the estrogen and progesterone levels and 80 contractions of the uterus compared to oxytocin.Conclusion The results indicate that the ethanolic extract of Gloriosa superba Linn had antiestrogenic and antiprogestogenic potential in OVX rats based on the physical histological and biochemical analyses. EyGS showed uterotonic activity in vitro and proves the folklore use of Gloriosa superba Linn.Keywords Gloriosa superba uterotrophic assay estrogenic vaginal cornification