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The aim of the present study was to investigate the effect of sucralfate pretreatment on the pharmacokinetics of rosiglitazone following a single oral dose in healthy male volunteers. After an over night fast, and according to a randomized schedule, each volunteer (n = 9) received a single oral dose of rosiglitazone 8 mg (Avandia tablets, 4 mg x 2) with or without pretreatment of sucralfate 2 g (Recolfate tablets, 1 g x 2) in an open-label crossover study with a 2-week washout period. Plasma samples were collected over a period of 24 hours at regular intervals. Safety assessment included monitoring of the vital signs, blood parameters, and ECG. No statistically significant differences (p > 0.05) were observed for any of the calculated rosiglitazone pharmacokinetic parameters in the two treatment groups. The mean parameters, AUC0-infinity and Cmax, following rosiglitazone administration alone were 3825.02 ng x h/ml and 664.47 ng/ml, respectively, and for rosiglitazone administered after pretreatment with sucralfate were 4848.19 ng x h/ml and 624.88 ng/ml, respectively. The t(max) for rosiglitazone alone and for rosiglitazone after sucralfate treatments was 1.11 and 1.67 hours, respectively. The mean elimination half-life for rosiglitazone and rosiglitazone after sucralfate treatment was 4.35 and 4.51 hours, respectively. Fraction of rosiglitazone absorbed was calculated by the Wagner-Nelson method, and no statistically significant difference (p > 0.05) was observed for the two treatments. Since sucralfate pretreatment did not show any significant difference in the pharmacokinetics of rosiglitazone, no dose adjustment is warranted for rosiglitazone when it is administered with sucralfate.

Understanding system-bath correlations in open quantum systems is essential for various quantum information and technology applications. Derivations of most master equations (MEs) for the dynamics of open systems require approximations that mask dependence of the system dynamics on correlations, since the MEs focus on reduced system dynamics. Here we demonstrate that the most common MEs indeed contain hidden information about explicit system-environment correlation. We unfold these correlations by recasting the MEs into a universal form in which the system-bath correlation operator appears. The equations include the Lindblad, Redfield, second-order time-convolutionless, second-order Nakajima-Zwanzig, and second-order universal Lindblad-like cases. We further illustrate our results in an example, which implies that the second-order universal Lindblad-like equation captures correlation more accurately than other standard techniques.

Superconducting Josephson junction qubits constitute the main current technology for many applications, including scalable quantum computers and thermal devices. Theoretical modeling of such systems is usually done within the two-level approximation. However, accurate theoretical modeling requires taking into account the influence of the higher excited states without limiting the system to the two-level qubit subspace. Here, we study the dynamics and control of a superconducting transmon using the numerically exact stochastic Liouville–von Neumann equation approach. We focus on the role of state leakage from the ideal two-level subspace for bath induced decay and single-qubit gate operations. We find significant short-time state leakage due to the strong coupling to the bath. We quantify the leakage errors in single-qubit gates and demonstrate their suppression with derivative removal adiabatic gates (DRAG) control for a five-level transmon in the presence of decoherence. Our results predict the limits of accuracy of the two-level approximation and possible intrinsic constraints in qubit dynamics and control for an experimentally relevant parameter set.

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