Background and Objectives:Exercise-induced desaturation (EID) is associated with increased mortality in chronic obstructive pulmonary disease (COPD). However, the relationship of EID with anthropometric and clinical parameters of resting pulmonary function test and six-minute walk test (6MWT) in COPD remains unclear. The study was designed to assess the correlate of EID and to identify various possible predictors of EID in stable normoxemic patients of COPD.Materials and Methods:Sixty patients with stable COPD diagnosed and staged as per the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines underwent 6MWT. A drop in standard pulse oximetry (SpO2) of ≥4% or nadir up to ≤88% was defined as EID. Based on EID during 6MWT, two groups were formed: desaturators (DS) and nondesaturators (NDS). DS and NDS were compared for baseline and clinical characters by the Student's t-test while Pearson and Spearman rho correlation coefficient assessed strength of the association of anthropometric and clinical variables with EID. The predictors of EID were identified by logistic regression and receiver operator curve analysis.Result:Out of 60 patients with stable COPD, 33 patients desaturated on exercise (n = 33/60). DS had significantly lower values of FEV1 (P < 0.001), FVC (P < 0.01) FEV1/FVC (P < 0.01) compared to NDS. EID had significant negative correlation with FEV1 (r = 0.31, P < 0.01), resting oxygen saturation (r = 0.549, P < 0.001) and 6MWD (r = 0.511, P < 0.001). Resting SpO2 ≤93% was found to a predictor of EID with a sensitivity and specificity of 83% and 78%, respectively.Interpretation and Conclusion:The 6MWT is a safe and sensitive test to recognize EID in normoxic stable COPD patients. Resting oxygen saturation is a good predictor of EID.
Introduction: Acute pancreatitis is a life threatening inflammatory disease with high morbidity and mortality. Multiple markers are used to predict severity of pancreatitis. An effective marker would help greatly in early diagnosis of disease severity and thus help in timely treatment.The present study attempted to evaluate blood platelet levels as a marker for assessing the severity of acute pancreatitis.Material and methods:37 patients with acute pancreatitis admitted in Department of Surgery IGMC Shimla were included in the study after taking informed consent. Patients were evaluated and diagnosed with acute pancreatits using blood investigation (serum amylase) as well as imaging modalilities(ultrasound and contrast enhanced CT scan). Patients blood platelets level were compared on day 1 and day 5 of admission in mild and severe pancreatitis patients.Results were then analysed statistically.
Results:On statistical analysis a platelet count of ≤ 150 m/ mm3 was found to be statistically significant on both day 1 (p=0.008)) and day 5 (p=0.001) of admission between patients with mild and severe pancreatitis.
Conclusion:Platelets level can function as a cost effective good prognostic marker for assessing severity of pancreatitis.
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