Background: Menopause is regarded as the marker for various symptoms such as physical, psychological, vasomotor, and sexual impairing the quality of life (QOL). Objectives: To assess the menopause-related QOL and determine associated factors among postmenopausal women. Materials and Methods: A cross-sectional study was conducted among 378 postmenopausal women attending the obstetrics and gynecology department of a tertiary care hospital using a standardized menopause-specific QOL (MENQOL) questionnaire consisting of physical, vasomotor, psychosocial, and sexual domains. Results: The study included 378 women aged above 40 years, with majority belonging to the age group of 46–50 years. The total MENQOL mean score was found to be 19.35 ± 16.20, with physical domain score the highest 14.89 ± 11.85, followed by vasomotor 1.98 ± 3.83, psychosocial 1.82 ± 3.29, and the least as sexual domain with score of 0.624 ± 2.21. Post menopausal women with age less than 50 years, No formal education, High socio-economic status, Home makers and duration of menopause less than 5 years was found to have statistical significant association with higher vasomotor domain score; No formal education, higher socio economic status and duration of menopause with greater than 5 years was found to be significant with higher sexual domain scores. Conclusions: Menopause may be associated with a decrease in QOL. Certain sociodemographic variables showed a statistically significant association with the vasomotor and sexual domains. Awareness and interventions that affect the modifiable factors may help in increasing the QOL at menopause.

<p class="abstract"><strong>Background:</strong> Any undesirable change in the structure or function of the skin and its appendages related to drug eruption regardless of the aetiology is called the cutaneous adverse drug reaction (CADR).  Manifestations are varied with diverse morphological pattern ranging from trivial urticarial to severe form of vasculitis which are fatal. Identifying the culprit drug in this new era with advanced development of multi drugs is a challenging task and can help in prevention of further complications and provide safer drugs. Objective of the study was to assess the clinical profile and causality of CADR among patients in a tertiary care hospital of Hyderabad.</p><p class="abstract"><strong>Methods:</strong> An observational hospital-based study was undertaken over a 6 months period among patients attending dermatology OPD of medical college and hospital located at Hyderabad. Patients presenting with suspected drug-related cutaneous lesions were included where the drug responsible was ascertained. Drug history was recorded in a format specified in Indian National Pharmacovigilance Programme and causality assessment carried out as per world health organization-uppsala monitoring centre criteria.<strong></strong></p><p class="abstract"><strong>Results:</strong> The study population consisted of females (52.4%) and males (47.6%). Majority of them were in the age group of 51-60 years. Most common pattern of CADR noted were urticaria (19.05%) followed by erythema multiforme (17.46%) and morbilliform rash (17.46%). The common drugs categorised for these reactions comprised of antibiotics (39%), nonsteroidal anti-inflammatory drugs (26%) followed by anti tubercular treatment (18%).</p><p class="abstract"><strong>Conclusions:</strong> CADR contribute to significant morbidity among industrial workers and role of pharmacovigilance should be further emphasized to reduce such reactions.  </p>

Background Declining lung functions is associated directly with cardiovascular diseases like heart failure or coronary artery disease, or the risk factors leading to cardiovascular mortality like arterial stiffness, pulse wave velocity, hypertension, etc. Exclusive studies in women are not frequently performed. Aim The aim is to study the association between obstructive lung function estimated through spirometry and cardiovascular risk indicators like hypertension and arterial pulse wave velocity measured between carotid and femoral arteries (cf-PWV) in women. Methods A total of 30 postmenopausal women on regular treatment for hypertension were recruited in the study. They were subjected to spirometry and computerized cf-PWV estimation. Women were grouped according to modified global initiative for chronic obstructive lung disease (GOLD) criteria into three groups with increasing severity of obstructive lung function. Results Diastolic blood pressure (p = 0.04), pulse pressure (p < 0.0001), and cf-PWV (p = 0.009) were found to be significantly different between the three groups. Negative correlation existed between cf-PWV and %pred forced expiratory volume in 1 second (FEV1) in the group with most severe obstructive lung function (Pearson correlation coefficient r = 0.7610 was significant at p = 0.01). The strength of this negative association decreased as the severity deceased (r = 0.5603, significant at p = 0.03). Conclusion Strong association between severity of obstructive lung function in postmenopausal women with pulse pressure was in lines with previous studies, but the diastolic blood pressure being associated is a novel finding. Also, the degree of obstructive lung function is positively associated with arterial stiffness which is an important indicator for impending cardiovascular mortality.

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Background and Aim Psoriasis have a direct impact on development of cardiovascular risk factors leading to atherosclerosis and metabolic abnormalities. In order to prevent the complications, early and prompt identification of factors through various parameters help in primary and secondary prevention of cardiovascular diseases (CVDs) among these psoriatic patients. Therefore the aim of this study is to determine the prevalence of various determinants for cardiovascular diseases among cases and controls. Methods A hospital based case control study at a tertiary care hospital included women from the out patient department, aged above 18 years who were known cases of psoriasis. 114 patients were recruited with 1:1 ratio between cases and controls. All patients were evaluated using semi structured interview schedule with socio demographic variables, duration of disease, family history, and usage of drugs. Severity of disease was assessed through the psoriasis area severity index (PASI). Body surface area (BSA), body mass index (BMI), waist circumference and blood pressure measurement were done using standard methods. Lipid profile, high sensitivity C-Reactive protein (HsCRP) and blood sugar through calibrated analyzers having quality control. Carotid intima media thickness (CIMT) was assessed by using carotid Doppler technique to measure atherosclerosis. Results One hundred fourteen patients, means 57 pairs of cases and controls were analyzed in this study. Significant determinants among cases were raised such as waist circumference (p = 0.025), diastolic blood pressure (p = 0.0001), low density lipoprotein (p = 0.002) and fasting blood glucose (p = 0.004) when compared to controls. HsCRP and CIMT were also raised among cases but only CIMT was statistically significant when compared to controls (p = 0.0001). We also found raised determinants among psoriatic arthritis patients compared to psoriasis. Conclusion Psoriasis patients had high waist circumference, diastolic blood pressure, low density lipoprotein, fasting blood glucose, and CIMT when compared to controls. Early identification of these determinants make them amenable for prevention.