Serous tubal intraepithelial carcinoma is a precursor lesion for high-grade pelvic serous carcinoma. The incidence is 0.6%–6% in tubectomy specimens of women who are BRCA-1,2 positive or have a strong family history of breast or ovarian cancer. STIC in women who do not have BRCA-1,2 mutations or concomitant high-grade serous carcinoma is exceedingly rare. Ectopic tubal gestation coexisting with serous tubal intraepithelial carcinoma is very rarely reported. These lesions pose considerable difficulty in the diagnosis. A combination of histology and immunohistochemical expression p53 and ki67 substantially improves the reproducibility of the diagnosis. Diagnosing these lesions will help identify potential at risk patients and their families for carcinoma. Adequate prolonged follow-up for incidental serous tubal intraepithelial carcinoma is the mainstay. We report one such case of a 31-year-old female who was operated for the right tubal gestation and found to have serous tubal intraepithelial carcinoma.
Invasive papillary carcinoma (IPC) of the breast is a rare entity, comprising approximately <1%–2% of all breast cancers. It is most commonly seen in postmenopausal females and rarely seen in males. IPC is arising from the dilated duct or large duct. They are low-grade tumors microscopically consisting of well-circumscribed solid nodules of the neoplastic cells separated by fibrovascular cores. It has excellent prognosis, so exact diagnosis is necessary. We report a case of a 68-year-old postmenopausal female, who came with complaints of a lump in the left breast for the past 2 months, modified radical mastectomy was done, and the specimen was sent for histopathological examination. Immunohistochemistry was done estrogen receptor and progesterone receptor positive with human epidermal growth factor receptor 2 negative. The case is presented due to its rarity.
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