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Objective: To explore the perception and attitude about simulation-based learning (SBL) of clinical skills in undergraduate medical students.Place and Duration of Study: College of Medicine, Princess Noura bint Abdulrehman university; Riyadh, Saudi Arabia, from March to September 2019.Method: A pre-tested structured self-administered questionnaire was used to collect the data about student’s perception about simulation-based learning. Informed written consent was taken from the students. Data analysis was done by SPSS version 21 and Chi square test was used to see the association between the variables of the interest.Result: Mean age of the students was 21.5 (standard deviation ±1.8) years. Majority of the students (81.6%) found SBL as a favorable mode of learning clinical skills. 59% of the students found it useful to manage to see the rarest cases in medicine. Many of them believed it useful to overcome the problems of uncooperative patients (59.1%) and to solve the problem in getting the patients during exam (60.2%). They also strongly believed that simulation should be integrated in medical school curriculum as an efficient tool for learning clinical skillsConclusion: The study strongly suggests student’s positive perspective towards learning through simulation. Medical educators and curriculum designers can use the results of the study to incorporate simulation in undergraduate curriculum to train and enhance student’s clinical skills and maintain patient safety.