Influenza is an infectious disease of the respiratory system caused by the influenza virus. Influenza virus RNA polymerase (RdRp) is essential in viral RNA replication and transcription. This polymerase has acid polymerase (PA) and polymerase basic 1 (PB1) subunits responsible for viral endonuclease and proteolytic activity. This study aims to determine the potential and interactions of the biochemical constituents of turmeric (Curcuma longa) and bitter (Andrographis paniculata) against the polymerase PA-PB1 (PDB ID: 3CM8) from the influenza A virus. The study was carried out using the molecular docking workflow method with a combination of standard-precision (SP), extraprecision (XP), and induced fit docking (IFD) utilizing the Maestro's Schrodinger. The docking result successfully identified seven compounds in C. longa and thirty-four in A. paniculata, which had a better docking score than R151785 as a reference ligand. XP docking showed compounds 1 from C. longa with a score of -7.555 kcal/mol and 4 from A. paniculata with a score of -9.156 kcal/mol. The IFD method results identified compounds 3 from C. longa and 5 from A. paniculata as potential compounds in inhibiting the activity of the polymerase PA-PB1 with a docking score of -9.979 kcal/mol, and -13.153 kcal/mol, respectively. All the best compounds interacted with critical residues such as Thr7,