Armodafinil the R-enantiomer of modafinil is involved in managing sleep disorder consisting of excessive sleepiness associated with obstructive sleep apnea, narcolepsy and shift work disorder. The aim of the study was to establish bioequivalence and tolerability between two formulations of armodafinil. This was an oral comparative bioequivalence study in healthy Indian subjects. The study design was a crossover, randomized, open label singledose, two-treatment, two-period, two-sequence type. Under fasting condition all the subjects (26 + 4 stand-by) received test and reference formulation in a staggered manner by a randomization code list in both the period with a washout period of seven days between the treatment periods. Twenty blood samples were drawn from each subject over 96 hours in each period. Liquid-liquid extraction method was validated using high performance liquid chromatography. The pharmacokinetic parameter C max (ng/ml), T max (hr), AUC (0-t) (ng/ml*hr), and AUC (0-∞) (ng/ml*hr), T ½ (hr) and K el (hr-1) were determined for armodafinil in reference and test formulations. ANOVA showed no significant variation in these parameters. Relative bioavailability of 97.78% was calculated for armodafinil. The 90% confidence interval of log transformed data comparing test formulation versus reference formulations for C max , AUC (0-t) and AUC (0-∞) are within the acceptance range of bioequivalence (80% to 125%). Based on the pharmacokinetics parameters of armodafinil (test and reference), it is concluded that single dose of single dose of armodafinil tablet containing 250 mg armodafinil manufactured by Emcure Pharmaceuticals, India., is bioequivalent to single dose of Nuvigil tablet containing 250 mg armodafinil manufactured by Cephalon, Inc., USA.

Objective: To find out an association, if any, between dermatoglyphic patterns of hands in Idiopathic Generalized Epilepsy of both sexes. Introduction: Genetic etiology has been proposed for both idiopathic epilepsy and dermatoglyphics. Hence, the present study has been undertaken to find out the existence of any correlation between dermatoglyphics and Idiopathic Generalized Epilepsy.