BackgroundCOVID‐19 is associated with increased nursing workload, therefore a high nurse‐to‐patient ratio would be required.AimTo analyse difference in nursing workload, as expressed with the Nursing Activities Score (NAS), between COVID‐19 patients versus control patients without COVID‐19 disease (NCOVID‐19 group) in an Italian Extracorporeal Membrane Oxygenation (ECMO) centre.Study DesignRetrospective analysis of prospectively collected data, enrolling consecutive patients admitted to a general Intensive Care Unit, between 1st May 2019 and 28th February 2021. A multivariate analysis was then performed to assess if COVID‐19 disease was an independent predictor of higher NAS and to assess which other factors and procedures are independently associated with increased workload.ResultsWe enrolled 574 patients, of which 135 (24%) were in the COVID‐19 group and 439 (76%) in the NCOVID‐19 group. The average NAS was higher in the COVID‐19 group (79 ± 11 vs. 65 ± 15, T = −10.026; p < 0.001). Prone positioning, continuous renal replacement therapy (CRRT) and ECMO were used more frequently in the COVID‐19 group. A higher fraction of patients in the COVID group showed colonization from multidrug resistant bacteria. COVID‐19 group had a higher duration of mechanical ventilation and longer ICU stay. The COVID‐19 diagnosis was independently associated with a higher NAS. Other independent predictors of higher NAS were the use of prone positioning and continuous renal replacement therapy (CRRT). Colonization from multidrug resistant bacteria and ECMO support were not independently associated with higher NAS.ConclusionsThe higher nursing workload in COVID‐19 patients is mainly due to specific procedures required to treat the most hypoxemic patients, such as prone positioning. Colonization with multidrug resistant bacteria and ECMO support were not independently associated with a higher NAS.Relevance to Clinical PracticeHigher workload in COVID‐19 patients was due to specific interventions, such as prone positioning and CRRT, with the related nursing activities, as continuous presence at patient's bed, mobilization, positioning and complex hygienic procedures.