Objective: To find an association between estrogen and progesterone with ovarian cancer progression. Study Design: Cross-sectional study Place and Duration of Study: Department of Obstetrics & Gynaecology, Islam Teaching Hospital, Sialkot from 1st January 2021 to 31st December 2021. Methodology: One hundred participants were enrolled. Ovarian cancer women were placed in Group A while healthy woman in Group B. The study was approved from the review board. The age of the patients was between 18-45 years. Demographic details as well as clinical and relevant familial history was documented of each patient. The blood sampling was done on same menstrual day 12 in each patient. Each patient 4 cc blood was withdrawn for analysis if their estrogen and progesterone levels. The blood was collected in serum vials and serum was separated by centrifugation at 3000rpm. The patients who were confirmed for ovarian cancer CA 125 were confirmed through clinical diagnosis in addition to their MRI and CT scan imaging. Results: The mean age of the patients was 33.3±2.1 years of ovarian cancers while 21.5±3.4 years of normal controls. Majority of the females were from low socioeconomic class. The values of progesterone and estrogen were significantly higher in CA 125 cases such as Group A in comparison with group B respectively. The analytes were assessed in the follicular phase and showed higher frequency in 96% and 94% of cases with ovarian cancer. The mean value was 2±0.4ng/ml and 119.1±2.9 pg/ml respectively. Conclusion: In ovarian cancer, level of estrogen was very higher during follicular phase. Keywords: Ovarian cancer, Advanced epithelial cancer, Estrogen, Progesterone, Abnormal secretion

Objective: To find the levels of C-reactive protein pregnant women and its relation with preeclampsia in singleton pregnancy. Study Design: Case control study. Place and Duration of Study: Department of Obstetrics & Gynaecology, Mohtarma Benazir Bhutto Shaheed Medical College, Mirpur Azad Kashmir from 1st July 2021 to 30th June 2022. Methodology: One hundred preeclampsia and 50 control women were enrolled. Protein in the urine presenting renal impairment, decrease platelet counts and renal disease were assessed. Cases that had a blood pressure which was chronically high in cases prior to gestation or were chronic renal disease patients were excluded from the study. A biochemical analysis of C-reactive proteins was conducted through ELISA. The results were than interpreted in terms of their association with preeclampsia. Demographic details and clinical parameters as body mass index (kg/m2), familial history, any related comorbidities, clinical signs and symptoms were documented. Results: The mean age of the preeclampsia women was 31.3±3.2 years while that of pregnant women who were normal controls as 25.8±3.8 years. Primigravida was higher in preeclampsia women while multigravida was higher in normal control pregnant women. Hypertension was prevalent in 73% of the preeclampsia cases than 10% of the normal control pregnant cases. Urinary protein was high as 2 gm in 51% cases of preeclampsia The C-reactive protein value was also significantly higher in preeclampsia cases than normal controlled pregnant women. Conclusion: There is a direct significant association between preeclampsia and high levels of C-reactive proteins. Keywords: C-reactive protein, Pre-eclampsia, Pregnancy