ABSTRACT:Motor vehicles have significantly recognized to have a role in air pollution. The emissions regarding particles and gasses have identified to affect human health depending on the concentration, constituents, kind of vehicles, and fuels. This study investigated the impacts of the petrol and diesel car smoke on mice lung. The aims were to observe the mice lung injury caused by the smoke exposures emitted by petrol and diesel car. The lung injury was identified by using the histological images. The mice were exposed to the smoke with a particular concentration conducted by introducing the smoke into the chamber with the dimension of 30x20x20 cm 3 as long as 40 seconds. The mice exposures were carried out daily for eight days. The lung injury was observed using a Binocular BX-51 Computer Microscope with the 400x magnification to the histological images. We identified the healthy cells and damage cells to determine the lung damage showed by the destructive index. The results showed that the mice exposed to diesel cars have higher index rather than those with the petrol car exposures.