Cognition is the process of identifying, selecting, interpreting, filtering, and using information that makes sense. It encompasses a complex function concerning the domains of memory, executive, attention, perception, language, and psychomotor. Consequently, impaired cognitive function in adulthood might potentially lead to a decrease in the function of daily activities, increase the injury risk, require the attention of caregivers, and increase death risk. In adulthood, this function is affected by education level, physical activity, sedentary behaviour, stress, disease history, history of head injury, and Body Mass Index (BMI). Physical activity plays an important role in brain health across all age groups, specifically among young adults, which is the peak of changes in certain cognitive abilities. Furthermore, it consists of sedentary behaviour, as well as very mild, mild, moderate, heavy, and very heavy physical activity. Watching television, sitting in front of a computer, driving a vehicle, sitting at work, playing, sitting while listening to songs are physical activities that include sedentary behaviour. Prolonged sedentary time potentially affects areas of cognitive function causing weaker executive function and slower processing speed. Currently in Indonesia, the adult age group above 18 years is still dominated by obesity and malnutrition problems. Meanwhile, both high BMI and obesity are associated with low-grade chronic inflammation and elevated pro-inflammatory cytokines, which explains the detrimental effects of cognitive function. This indicates a high BMI causes lower cognitive performance in the areas of attention and impulsivity compared to individuals with a normal value. The purpose is to review the effect of sedentary behaviour and BMI on-cognitive decline in-young adults. Journal searches are conducted by researchers by looking from various sources such as PubMed / NCBI, google scholar, science direct by entering the initial keyword sedentary behaviour, which is then followed by other keywords namely cognitive, body mass index, and young, adults. The result of this review is the effect of sedentary behaviour on the cognitive decline is due to different physiological responses at the molecular level in obese individuals or others with excess BMI which decreases cognitive function through several mechanisms such as low-grade chronic inflammation, brain structural changes, and changes in leptin levels. Conclusion based on a literature review is sedentary behaviour and higher BMI can decline the cognitive function.