support of my M.Sc study and research, for his patience, motivation, guidance, criticizing, immense knowledge, but specially, thanks for be my friend. Thanks for always finds the time for listening to the little problems that unavoidably crop up in the course of performing research. You are one of the clearest examples to follow in my professional life. I express my gratitude to Prof. Dr. Carina Ulsen for her guidance helped me in all the time of research and valuable support in lab during my experiments. Thank you because you and Prof. Jean believed in me at all times. My thanks also go to the members of my major committee for reading this dissertation and providing many valuable comments that improve this research.