Objective of research: the study on tolerability and therapeutic efficacy of the complex drug Helmintal produced on the basis of two ingredients moxidectin and praziquantel. Materials and methods: In our research, we used four drug modifications: for cats and kittens weighting less than 4 kg (moxidectin 0.4 mg and praziquantel 10 mg); for cats — more than 4 kg (moxidectin 1.6 mg and praziquantel 40 mg); for dogs and puppies — less than 10 kg (moxidectin 1 mg and praziquantel 25 mg); for dogs — more than 10 kg (moxidectin 5 mg and praziquantel 125 mg.) To study the effect of the drug on the organism, three groups of clinically healthy animals were formed (5 animals per group): dogs 1 — 2 years of age with the body mass 18 — 20 kg; puppies 3 — 5 weeks of age weighting 0.8 — 1 kg; cats 1 — 2 years of age weighting 3 — 5 kg; kittens 6 — 8 weeks of age with the body mass 0.6 — 0.8 kg. The drug was given to animals orally once a day in the morning within 7 days in the following doses: the first experimental group — 0.4 mg moxidectin and praziquantel 10 mg per 1 kg of body weight (double therapeutic dose); the second group — moxidectin 1.0 mg and praziquantel 25 mg per 1 kg of body weight (five-fold therapeutic dose); the third group served as controls — the drug was not used. During the experiment, animals were monitored daily, their general health status, behavior, appetite were observed, weight and body temperature controlled. Before and 15 and 30 days after the beginning of the drug taking, several morphological and biochemical parameters of blood and urine were investigated. The study of the anthelmintic efficacy of the drug was carried out on the basis of veterinary clinics in Moscow and Moscow region. Altogether 205 cats and 209 dogs spontaneously infected were chosen for the experiment. The diagnosis and the drug efficacy were confirmed based on the clinical picture and on Fulleborn’s method used for detection of helminth eggs in animal’s feces followed by differentiation. Results and discussion: During the study on the drug tolerance it was found that the general status, mass and the body temperature of animals from experimental groups did not significantly differ from controls. Morphological and biochemical parameters of blood and urine in all animals from experimental and control groups did not differ significantly and were within the physiological norm before and after treatment. Thus, the research allows to conclude that the drug applied within 7 days at double and fivefold therapeutic doses has no adverse effect on dogs, puppies, cats and kittens. Most sick animals used in the experiment on the effectiveness of the drug, were emaciated, listless, their fur was ruffled, mucous membranes were pale; they suffered from anal itching, diarrhea and fecal retention. The drug was given after diagnosis; many dogs and cats ate it themselves, and other had no problems with eating pills due to their small size and pleasant taste. When applying the drug and throughout the experiment, no side effects and complications were observed in all animals. 10 and 20 days after giving the drug, its efficacy in the treatment of nematodosis and cestodosis of adult dogs cats as well as kittens and puppies was 100%.

This article presents the results of studies of the therapeutic and prophylactic efficacy of the drug "Neoterica Protecto Syrup" for arachnoentomoses and nematodes of domestic carnivores. The drug contains the active ingredient moxidectin, which provides a wide range of antiparasitic action of the drug against ecto- and endoparasites. The studies were conducted from April to August 2020 in veterinary clinics in Moscow and the Moscow region on dogs and cats free from parasites and naturally infested with fleas, lice, ixodid and scabies mites, intestinal nematodes and dirofilaria larvae. The animals were administered the drug once orally individually at a therapeutic dose at the rate of 1.5 mg moxidectin per 1 kg of animal weight. The diagnosis and efficacy of the diseases were confirmed by clinical (examination of the skin and hair for the presence of ectoparasites) and laboratory (Priselkova's method for detecting acariform mites in scrapings, the "thick crushed drop method" for detecting dirofilariae, Fülleborn's method for detecting nematode eggs) studies have confirmed the therapeutic efficacy the drug, the antiparasitic activity persisted for 90 days after application, which confirms the preventive effectiveness of the drug.

This article presents the results of studies of the toxicological characteristics of a longacting veterinary medicinal product "Neoterica Protecto Syrup" based on moxidectin in the form of an oral solution. Acute oral toxicity was studied in white mice and white rats. As a result, the LD50 of the drug was 4300 mg/kg for male and female mice, 3500 mg/kg for male rats, and 5700 mg/kg for female rats, and on the basis of which it was established that the drug belongs to the 3rd hazard class (moderately hazardous substances) according to GOST 12.1.007-76. Acute cutaneous toxicity was investigated and the irritant effect of the drug on white rats was assessed, for the drug the 4th hazard class (low-hazard substances) was established according to GOST 12.1.007-76. The subchronic toxicity of doses of 1/10, 1/20 and 1/50 of the LD50 of the drug, established in an acute experiment, with daily use for 5 days was studied in white rats. As a result, it was found that doses of 350, 175 and 70 mg/kg with daily use in white outbred rats for 5 days are inoperative.

Aphanipterosis is a parasitic disease which is caused by fleas Siphonaptera parasitizing on an animal body. In 97 per cent of the cases the fleas Ctenocephalides canis and Ctenocephalides felis parasite on dogs and cats.The therapeutic efficacy of complex drugs «INSPECTOR QUADRO С» and «INSPECTOR QUADRO К» at aphanipterosis in dogs and cats was examined. The drugs were tested in veterinary clinics in Moscow and Volgograd. The drugs are in the form of topical solutions and contain fipronil, pyriproxyfen, praziquantel and moxidectin as active ingredients.The efficacy of drugs was studied on spontaneously infested dogs and cats. Before the experiment skin and hair of animals were examined and a quantity of ectoparasites (example/animal units) was defined. Dogs and cats were divided by the principle of couples analogs into two groups taking into account age, weight and the physiological status of an animal: experimental and control. The animals were treated once according to instructions for use. Monitoring of drug efficacy was carried out in 24 hours, 14 and 30 days after treatment. During researches animals were observed: the general condition, behavior, receiving of food and water, appearance of allergic reactions were noted, skin and hair were examined.Upon examination of dogs and cats infested by fleas, no fleas were found on skin and hair in 14 days after treatment. No living insects were found at further observation of experimental animals within 30 days. Thus, the therapeutic efficacy of complex drugs «INSPECTOR QUADRO С» and «INSPECTOR QUADRO К» at aphanipterosis in dogs and cats was 100%. No adverse effects and complications in animals were found.