Introduction: Lupus is a systemic autoimmune disease with multi organ involvement that develops a variety of clinical manifestations from dermatological ones to severe organ damage. Covid 19 is an infection with high mortality and morbidity, caused by the novel severe acute respiratory syndrome (SARS) coronavirus 2 (CoV2). There are hypotheses on a burst of clinical manifestations of Systemic Lupus Erythematosus (SLE) after Covid 19, based on different literature reports. Here we present a clinical case of SLE with organ involvement, which aggravated after infection with SARS Cov2. Clinical case: A 30 year old young woman presented with aggravation of her musculoskeletal symptoms after infection with Covid 19. Before the coronavirus infection, she had joint pain, fatigue and subsequently developed systemic multiorgan involvement like lupus nephritis, pulmonary and hematological involvement. The patient gets diagnosed with SLE and begins treatment with Methylprednisolone 1 gram/day for three days, followed by ACE I (Ramipril 5 mg 1 tab/day), Mycophenolate 3 gram/day, Plaquenil 200 mg/day, Prednisone 1mg/kg body weight, Calcium, Vitamin D, PPI. Conclusion: With this clinical case we underline a hypothesis of a burst of clinical manifestations of autoimmune diseases, SLE in this case, probably because of a high titer of antibody production after infection with Covid 19.