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Aims: This study aimed to clinically evaluate of a novel gelatin-based biodegradable sponge after mandibular posterior teeth extraction to assess its abilities in controlling bleeding, pain, and dry socket compared a commercial sponge. Trial design: In this study, 26 patients who needed the extraction of two mandibular molar teeth were selected and, in each patient, after tooth extraction, the prepared gelatin sponge was used in the test group and the commercial sponge was used in the control group in the form of a randomized, double-blind, split-mouth clinical trial. The sterile gauzes were used on top of each sponge to absorb the extra blood (unabsorbed blood of sponges) to assess the blood absorption amount. Also, the amount of bleeding was recorded for 1 and 4 h after extraction for two groups. The amount of pain was measured for 12, 24, and 48 h after tooth extraction by Visual Analogue Scale (VAS). All patients also returned for examination four days after extraction to assess the occurrence of dry socket. Results: The results showed that the average weight of absorbed blood by sterile gauze in the control group (6.32 ± 1.06 g) was higher than in test group (3.97 ± 1.1 g), e.g., the bleeding control was better for the test group (p < 0.05). Bleeding was observed to be significantly reduced in the test group within 1 h (p = 0.003), within 1–4 h (p = 0.002), and after 4 h (p = 0.042) post-operatively in comparison to the control group. The average pain decreased significantly over time in both groups and the reduction of the pain was significantly higher for the test group (p < 0.05). Just one dry socket case occurred in the control group. Conclusion: The prepared sponge is recommended for use in dental surgeries because of its abilities in bleeding, pain, and dry socket control.

This study aimed to investigate fatigue and its effect on the quality of life in people with multiple sclerosis (MS) in Yasuj. This is a cross-sectional descriptive experimental study. The statistical population included all patients with MS in Boyer-Ahmad County (Yasuj) from weak to progressive levels. The statistical sample of this study included 122 men and women with MS who were selected by convenience sampling. Data collection tools in this study included the fatigue questionnaire (FSS) and quality of life questionnaire (WHOQOL). Data analysis was carried out using the statistical methods of mean, standard deviation, Pearson’s correlation and stepwise regression in Statistical Package for the Social Sciences 17. Based on the findings of the study, it can be concluded that there is a significant relationship between fatigue and quality of life among people with MS in Yasuj, and the more fatigue a person feels, the more affected their quality of life.   Keywords: Fatigue, life, multiple sclerosis, quality

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