BackgroundCoronavirus disease 2019 (COVID-19) might affect everyone, but people with comorbidities such as hypertension and cardiovascular disease (CVD) may often have more severe complications and worse outcomes. Although vaccinations are being performed worldwide, it will take a long time until the entire population of the world is vaccinated. On the other hand, we are witnessing the emergence of new variants of this virus. Therefore, effective therapeutic approaches still need to be considered. Statins are well-known lipid-lowering drugs, but they have also anti-inflammatory and immunomodulatory effects. This study aimed to investigate the effects of statins on the survival of COVID-19 hospitalized patients.MethodsThis retrospective study was performed on 583 patients admitted to a highly referenced hospital in Tabas, Iran, between February 2020 and December 2020. One hundred sixty-two patients were treated with statins and 421 patients were not. Demographic information, clinical signs, and the results of laboratory, and comorbidities were extracted from patients' medical records and mortality and survival rates were assessed in these two groups.ResultsThe results of the Cox crude regression model showed that statins reduced mortality in COVID-19 patients (HR = 0.56, 95% CI: 0.32, 0.97; p = 0.040), although this reduction was not significant in the adjusted model (HRs=0.51, 95%CI: 0.22, 1.17; p = 0.114). Using a composite outcome comprising intubation, ICU admission, and mortality, both crude (HR = 0.43; 95% CI: 0.26, 0.73; p = 0.002) and adjusted (HR = 0.57; 95% CI: 0.33, 0.99; p = 0.048) models suggested a significant protective effect of statin therapy.ConclusionDue to anti-inflammatory properties of statins, these drugs can be effective as an adjunct therapy in the treatment of COVID-19 patients.

Introduction: Air quality improvement was an unparalleled environmental consequence of the Covid-19 global crisis in many regions. Numerous researches have been conducted on the influence of national quarantines on air pollution and the relationship between the abundance of infected cases and mortality caused by this pandemic with air pollutants; however, these investigations are limited in Iran. The present study aims to investigate the correlation between Covid-19 cases and air pollution from a statistical viewpoint in order to evaluate the performance of multiple national lockdowns from February 2020 to August 2021 through measuring changes in air pollutants in the 31 provinces of Iran. Materials and methods: We applied a remote sensing method by employing Sentinel-5P satellite data to analyze changes in PM2.5, CO, and O3 during the three public quarantine periods and their two months earlier. Results: We recognized a considerable positive correlation between PM2.5 and the infected cases (r=0.63, p=0.001) and victims (r=0.41, p=0.001). Moreover, we compared the efficiency of lockdowns and supposed lockdown 2 (November-December 2020) as an only effective quarantine due to a dramatic reduction in PM2.5 (21.2%), CO (0.8%), the infected cases (48.7%), and victims (66.9%) in comparison to the average of its next two months. Conclusion: Governments should handle the outbreak of Covid-19 by implementing efficient quarantines, as well as environmental conservation strategies.

Background The aim of this study was to investigate the relationship of dietary total antioxidant capacity (DTAC) with sarcopenia and metabolic biomarkers in people with type 2 diabetes in the Kurdish race. Methods In this cross‐sectional study, data of 189 type 2 diabetic patients (35–65 years old) from RaNCD cohort study were evaluated. DTAC, fasting blood sugar, lipid profile, body composition, muscle strength, and sarcopenia were assessed. t and χ 2 tests to compare the variables between sarcopenic and non‐sarcopenic patients and one‐way analysis of variance to compare the variables in DTAC tertiles were used. The relationship between DTAC and different variables was evaluated using multiple logistic regression model. Results The mean age and body mass index were 49.7 ± 8.7 years and 27.1 ± 3.9 kg/m 2 . Body mass index, waist circumference, and hip circumference were significantly different between diabetic patients with and without sarcopenia ( p < 0.05). In crude ( p = 0.010) and adjusted ( p = 0.035) models, there was a significant relationship between DTAC and fasting blood sugar. Also, the relationship between DTAC with waist ( p = 0.019) and hip (β = −4.25, p = 0.026) circumference was significant. Sarcopenia was significantly lower in the third tertile in comparison with the first tertile of DTAC ( p = 0.016). Conclusion Diet with higher DTAC can be associated with lower fasting blood sugar, abdominal obesity and sarcopenia in type 2 diabetic patients. However, further studies are required to confirm these relationships.