Regions need to tailor their own place-based policies because there is no 'one-size-fits-all' regional innovation policy framework. Each region is characterized by different institutional capacities related to political, economic and social contexts enabling or constraining the design and implementation of placebased policies. This paper uses an instrumental-use multiple case study approach to explore the design and implementation of place-based policies within the institutional arrangements of four regional innovation agencies (RIAs) established in three different regional contexts inside and outside the European Union: one in the Brainport region (the Netherlands), two in the Basque Country (Spain) and one in Medellín (Colombia). In analyzing the RIAs' similarities and differences, this paper explores the complexity of designing and implementing place-based innovation policies in different regional innovation systems (RISs) while noting important policy implications for regional innovation governance and institutional arrangements to upgrade RIS in a more systematic manner. ARTICLE HISTORY

Innovation districts are emerging as place-based, knowledge-based urban development strategies in diverse cities around the world. They have, however, been criticized for being non-participative top-down initiatives that encourage gentrification and income, social, and racial polarization. In 2015, Mayor Berke launched Chattanooga's Innovation District in the city's downtown to accelerate the transformation of Chattanooga into a knowledge city. This paper investigates the programs that are being implemented in order to mitigate the negative externalities that such a strategy can generate. Using Chattanooga as an exploratory case, the authors argue that gentrification in innovation districts can increase knowledge spillovers.

The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.